Antinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious cats

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dc.contributor.authorSteagall, P. V. M.
dc.contributor.authorMillette, V.
dc.contributor.authorMantovani, F. B.
dc.contributor.authorGilbert, P.
dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorDuke-Novakovski, T.
dc.contributor.institutionUniv Wisconsin
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Saskatchewan
dc.date.accessioned2014-05-20T15:31:59Z
dc.date.available2014-05-20T15:31:59Z
dc.date.issued2009-10-01
dc.description.abstractThe aim of this study was to compare the antinociceptive effects of epidural buprenorphine (EB), epidural medetomidine (EM) or epidural buprenorphine-medetomidine (EBM). Eight cats were studied. Thermal thresholds (TT) were measured by increasing the temperature of a probe placed on the thorax. Mechanical thresholds (MT) were measured through inflation of a modified blood pressure bladder to the cat's forelimb. After baseline measurements, EB (0.02 mg/kg), em (0.01 mg/kg) or half of the doses of each drug (EBM) were administered. Data were analysed using anova (P < 0.05) and 95% confidence interval (CI). TT increased from 30 min to 1 h after EB and at 45 min after EM. MT increased from 45 min to 2 h after EB, from 15 min to 1 h after em and at 30, 45 min and at 2 h after EBM. MT were significantly lower after EB than em at 30 min. TT were above the upper 95%CI from 15 min to 24 h after EB, from 15 min to 4 h after em and from 15 min to 8 h after EBM. MT were above the upper 95%CI from 15 min to 5 h, and at 8, 12 and 24 h after EB, from 15 min to 6 h after em and from 15 min to 6 h and at 12 and 24 h after EBM. All treatments had similar onset. Overall, EB presented longer period of action than EBM and EM. The same magnitude of analgesia was achieved, but with fewer side effects when EBM was compared with EM.en
dc.description.affiliationUniv Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA
dc.description.affiliationSão Paulo State Univ, Sch Vet Med, Dept Vet Surg & Anesthesiol, São Paulo, Brazil
dc.description.affiliationUniv Saskatchewan, Western Coll Vet Med, Dept Small Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada
dc.description.affiliationUnespSão Paulo State Univ, Sch Vet Med, Dept Vet Surg & Anesthesiol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCompanion Animal Health Fund
dc.description.sponsorshipWestern College of Veterinary Medicine, Saskatoon, SK, Canada
dc.description.sponsorshipPfizer Canada Animal Health
dc.description.sponsorshipAlstoe Animal Health, UK
dc.description.sponsorshipAnimal Resources Departments
dc.description.sponsorshipAVA Alstoe Educational Travel
dc.format.extent477-484
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2885.2009.01069.x
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics. Malden: Wiley-blackwell Publishing, Inc, v. 32, n. 5, p. 477-484, 2009.
dc.identifier.doi10.1111/j.1365-2885.2009.01069.x
dc.identifier.issn0140-7783
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.urihttp://hdl.handle.net/11449/40988
dc.identifier.wosWOS:000269731200011
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.ispartofjcr1.441
dc.relation.ispartofsjr0,700
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAntinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious catsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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