Screening for In Vitro and In Vivo Antitumor Activities of the Mushroom Agaricus Blazei

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dc.contributor.authorZiliotto, Liane [UNESP]
dc.contributor.authorPinheiro, Fabriciano [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:27Z
dc.date.available2014-05-20T13:37:27Z
dc.date.issued2009-01-01
dc.description.abstractWe have investigated the in vitro antitumor activity of the mushroom Agaricus blazei Murill on human cancer cell lines as well as its potential anticancer activity in a model of rat colon carcinogenesis. The in vitro anticancer analysis was performed using 9 human cancer cell lines incubated with organic and aqueous extracts of A. blazei. Antitumor activity was observed with the dichloromethane/methanol and hexanic extracts of A. blazei at 250 g/ml for all cancer cell lines tested. No antiproliferative/cytotoxic activities were detected for the aqueous, methanol, ethyl acetate, or n-butanolic extracts. In the in vivo analysis, crude A. blazei was given orally after carcinogen treatment in a rat medium-term study (20 weeks) of colon carcinogenesis using aberrant crypt foci (ACF) as biomarker. Male Wistar rats were given dimethylhydrazine (DMH) and then were fed A. blazei at 5% in the diet until Week 20. ACF were scored for number and crypt multiplicity. A. blazei intake did not suppress ACF development or crypt multiplicity induced by DMH. No differences in tumor incidence in the colon were observed among the DMH-treated groups. Our results indicate that employing A. blazei in the diet does not have a suppressive effect on colon carcinogenesis.en
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNucleo de Avaliacao Toxicogenetica e Cancerigena (Toxican) Botucatu, SP, UNESP, Brazil
dc.format.extent245-250
dc.identifierhttp://dx.doi.org/10.1080/01635580802395717
dc.identifier.citationNutrition and Cancer-an International Journal. Philadelphia: Lawrence Erlbaum Assoc Inc-taylor & Francis, v. 61, n. 2, p. 245-250, 2009.
dc.identifier.doi10.1080/01635580802395717
dc.identifier.issn0163-5581
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/12964
dc.identifier.wosWOS:000263648400010
dc.language.isoeng
dc.publisherLawrence Erlbaum Assoc Inc-taylor & Francis
dc.relation.ispartofNutrition and Cancer-an International Journal
dc.relation.ispartofjcr2.261
dc.relation.ispartofsjr0,745
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleScreening for In Vitro and In Vivo Antitumor Activities of the Mushroom Agaricus Blazeien
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderLawrence Erlbaum Assoc Inc-taylor & Francis
unesp.author.lattes3278528112652257
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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