In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

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dc.contributor.authorCastro, Andreisa Teixeira de
dc.contributor.authorCastro, Aline Pereira
dc.contributor.authorSilva, Matheus Siqueira
dc.contributor.authorMonteiro de Souza, Isabella Maria
dc.contributor.authorMartins-Souza, Raquel Lopes
dc.contributor.authorChagas-Paula, Daniela Aparecida
dc.contributor.authorLeomil Coelho, Luiz Felipe
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorPivatto, Marcos
dc.contributor.authorViegas Junior, Claudio
dc.contributor.authorMarques, Marcos Jose
dc.contributor.institutionUniv Fed Alfenas Minas Gerais
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Uberlandia Minas Gerais
dc.date.accessioned2018-11-27T19:49:06Z
dc.date.available2018-11-27T19:49:06Z
dc.date.issued2016-09-01
dc.description.abstractIn this work, we present the in vitro schistosomicidal activity evaluation of the most active dichloromethane fraction (FDm) (ED50 = 83.5 mu g/mL) and of a mixture of the major alkaloids ((-)-cassine/(-)-spectaline, C/E) (ED50 = 37.4 mu g/mL) from the flowers of Senna spectabilis against adult worms and cercariae. We also demonstrate other toxic effects including paralysis of the adult worms, inhibition of the secretory activity, tegument lesions and cercaricidal activity. In the association test of Praziquantel (PZQ)-C/E, we observed up to 80% mortality of Schistosoma mansoni in comparison to PZQ monotherapy. Due to the diversity of the toxic effects, the schistosomicidal activity of C/E is likely a result of a multitarget mechanism involving the tegument, secretory system and neuromotor action. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Alfenas Minas Gerais, BR-37130000 Alfenas, Brazil
dc.description.affiliationUniv Estadual Paulista Sao Paulo, BR-14800060 Araraquara, Brazil
dc.description.affiliationUniv Fed Uberlandia Minas Gerais, BR-38408100 Uberlandia, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Sao Paulo, BR-14800060 Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent4197-4204
dc.identifierhttp://dx.doi.org/10.1016/j.bmcl.2016.07.058
dc.identifier.citationBioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-elsevier Science Ltd, v. 26, n. 17, p. 4197-4204, 2016.
dc.identifier.doi10.1016/j.bmcl.2016.07.058
dc.identifier.fileWOS000381959900008.pdf
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/11449/165283
dc.identifier.wosWOS:000381959900008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBioorganic & Medicinal Chemistry Letters
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSchistosomiasis
dc.subjectSenna spectabilis
dc.subjectAlkaloids
dc.subjectFluorescent probes
dc.titleIn vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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