Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorFunagoshi, Erica Emi [UNESP]
dc.contributor.authorde Oliveira, José Ricardo Soares [UNESP]
dc.contributor.authordo Sacramento, Luis Vitor Silva [UNESP]
dc.contributor.authordos Santos, André Gonzaga [UNESP]
dc.contributor.authorLeonardi, Gislaine Ricci
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-12-11T17:15:45Z
dc.date.available2018-12-11T17:15:45Z
dc.date.issued2017-01-01
dc.description.abstractThis study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders.en
dc.description.affiliationDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.affiliationDepartment of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.affiliationFaculty of Pharmaceuticals Sciences University of Campinas-UNICAMP
dc.description.affiliationUnespDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.affiliationUnespDepartment of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/17723-7
dc.identifierhttp://dx.doi.org/10.1590/s2175-97902017000300051
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 53, n. 3, 2017.
dc.identifier.doi10.1590/s2175-97902017000300051
dc.identifier.fileS1984-82502017000300609.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.lattes1427125996716282
dc.identifier.scieloS1984-82502017000300609
dc.identifier.scopus2-s2.0-85032660126
dc.identifier.urihttp://hdl.handle.net/11449/175419
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectLiquid crystals/evaluation/physical-chemical stability
dc.subjectMicroemulsions/evaluation
dc.subjectOrganic cocoa extract
dc.subjectSkin bioadhesion
dc.subjectSurfactant-based system
dc.titleOrganic cocoa extract -loaded surfactant-based systems intended to skin bioadhesionen
dc.typeArtigo
unesp.author.lattes4000625974516852[5]
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-4920-2506[5]

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Artigos - Fármacos e Medicamentos - FCFAR
Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR