Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol

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dc.contributor.authorSaad, William A. [UNESP]
dc.contributor.authorLuiz, A. C. [UNESP]
dc.contributor.authorCamargo, L. A A [UNESP]
dc.contributor.authorSilveira, J. E N [UNESP]
dc.contributor.authorFóglia, S. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:13Z
dc.date.available2014-05-27T11:18:13Z
dc.date.issued1997-04-01
dc.description.abstractWe investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.en
dc.description.affiliationDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.description.affiliationDepto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SP
dc.description.affiliationUnespDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.description.affiliationUnespDepto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SP
dc.format.extent493-496
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997000400010
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.
dc.identifier.doi10.1590/S0100-879X1997000400010
dc.identifier.file2-s2.0-0030958097.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes1023597870118105
dc.identifier.scieloS0100-879X1997000400010
dc.identifier.scopus2-s2.0-0030958097
dc.identifier.urihttp://hdl.handle.net/11449/65079
dc.identifier.wosWOS:A1997WT02000010
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectcarbachol
dc.subjectcentral angiotensin
dc.subjectpressor response
dc.subjectangiotensin
dc.subjectlosartan
dc.subjectlosartan potassium
dc.subjectramipril
dc.subjectanimal experiment
dc.subjectcholinergic system
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectintracerebroventricular drug administration
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectrenin angiotensin aldosterone system
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectCarbachol
dc.subjectCerebral Ventricles
dc.subjectCholinergic Agonists
dc.subjectLosartan
dc.subjectMale
dc.subjectPressoreceptors
dc.subjectRamipril
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReceptors, Angiotensin
dc.subjectRenin-Angiotensin System
dc.subjectAnimalia
dc.titleFunctional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbacholen
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm#Copyright
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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