Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

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dc.contributor.authorGunatilaka, AAL
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorDagne, E.
dc.contributor.authorHofmann, G. A.
dc.contributor.authorJohnson, R. K.
dc.contributor.authorMcCabe, F. L.
dc.contributor.authorMattern, M. R.
dc.contributor.authorKingston, DGI
dc.contributor.institutionVirginia Polytech Inst & State Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSmithKline Beecham Pharmaceut
dc.contributor.institutionUniv Addis Ababa
dc.date.accessioned2014-05-20T15:24:52Z
dc.date.available2014-05-20T15:24:52Z
dc.date.issued1998-02-01
dc.description.abstractBioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5),and Tr-B (7) and the novel seco-A protolimonoid 8. of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, C-13 NMR spectral assignments, and biological activities of:these compounds are reported.en
dc.description.affiliationVirginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil
dc.description.affiliationSmithKline Beecham Pharmaceut, Res & Dev, King of Prussia, PA 19406 USA
dc.description.affiliationUniv Addis Ababa, Dept Chem, Addis Ababa, Ethiopia
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil
dc.format.extent179-184
dc.identifierhttp://dx.doi.org/10.1021/np9701687
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 61, n. 2, p. 179-184, 1998.
dc.identifier.doi10.1021/np9701687
dc.identifier.issn0163-3864
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/35394
dc.identifier.wosWOS:000072377000002
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleLimonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emeticaen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/paragonplus/copyright/jpa_form_a.pdf
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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