Treatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats

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dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorFernandes, Leandro Araujo [UNESP]
dc.contributor.authorMacarini, Valmir Campos [UNESP]
dc.contributor.authorAlmeida, Juliano Milanezi de [UNESP]
dc.contributor.authorMartins, Thiago Marchi [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorCirelli, Joni Augusto [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.contributor.institutionEduc Fdn Barretos UNIFEB
dc.date.accessioned2014-05-20T13:45:33Z
dc.date.available2014-05-20T13:45:33Z
dc.date.issued2011-12-01
dc.description.abstractBackground: The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats.Material & Methods: A total of 240 rats were evenly divided into two groups: C - saline solution treatment; N - nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP - irrigation with saline solution; Toluidine Blue-O (TBO) - irrigation with phenothiazinium dye (100 mu g/ml); LLLT - laser irradiation (660 nm; 0.03 W; 4 J); and aPDT - TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed.Results: Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods.Conclusion: Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats.en
dc.description.affiliationSão Paulo State Univ, Grp Res & Study Laser Dent GEPLO, Dept Surg, Div Periodont, São Paulo, Brazil
dc.description.affiliationUniv Fed Alfenas, Dept Clin & Surg, Alfenas, MG, Brazil
dc.description.affiliationEduc Fdn Barretos UNIFEB, Dent Sch Barretos, Univ Ctr, Master Course, Barretos, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Diag & Surg, Div Periodont, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Grp Res & Study Laser Dent GEPLO, Dept Surg, Div Periodont, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Diag & Surg, Div Periodont, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 08/04927-3
dc.description.sponsorshipIdCNPq: 301085/2007-2
dc.format.extent1106-1114
dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2011.01785.x
dc.identifier.citationJournal of Clinical Periodontology. Malden: Wiley-blackwell, v. 38, n. 12, p. 1106-1114, 2011.
dc.identifier.doi10.1111/j.1600-051X.2011.01785.x
dc.identifier.issn0303-6979
dc.identifier.lattes4068921369233125
dc.identifier.lattes9831236034935598
dc.identifier.lattes8399870097572073
dc.identifier.lattes4774447118127346
dc.identifier.urihttp://hdl.handle.net/11449/16032
dc.identifier.wosWOS:000297866000006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofjcr4.046
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalveolar bone lossen
dc.subjectlasersen
dc.subjectnicotineen
dc.subjectosteoclastsen
dc.subjectperiodontitisen
dc.subjectphotochemotherapyen
dc.titleTreatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes2628593693450121
unesp.author.orcid0000-0002-7082-9290[8]
unesp.author.orcid0000-0002-6715-8334[1]
unesp.author.orcid0000-0001-5903-5652[7]
unesp.author.orcid0000-0002-5995-5747[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Diagnóstico e Cirurgia - FOAR