Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats

Página do item simplificado
dc.contributor.authorVilla, Patricia de Souza [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorPavan de Arruda Camargo, Gabriela Maria [UNESP]
dc.contributor.authorArruda Camargo, Luiz Antonio de [UNESP]
dc.contributor.authorSaad, Wilson Abrao [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniv Taubate
dc.date.accessioned2014-05-20T13:46:01Z
dc.date.available2014-05-20T13:46:01Z
dc.date.issued2008-10-09
dc.description.abstractThe paraventricular nucleus (PVN) may be considered as a dynamic mosaic of chemically-specified subgroups of neurons. 5-HT1A is one of the prime receptors identified and there is expressed throughout all magnocellular regions of the PVN. Several reports have demonstrated that a subpopulation of the magnocellular neurons expressing 5-HT1A receptors are oxytocin (OT) neurons and activation of 5-HT1A receptors in the PVN increases the plasma OT. Increasing evidence shows that OT inhibits water intake and increases urinary excretion in rats. The aim of this study was to investigate the role of serotonergic 5-HT1A receptors in the lateral-medial posterior magnocellular region of the PVN in the water intake and diuresis induced by 24 h of water deprivation. Cannulae were implanted in the PVN of rats. 5-HT injections in the PVN reduced water intake and increased urinary excretion. 8-OH-DPAT (a 5-HT1A agonist) injections blocked the water intake and increased urinary output in all the periods of the observation. pMPPF (a 5-HT1A antagonist) injected bilaterally before the 8-OH-DPAT blocked its inhibitory effect on water intake and its diuretic effect. We suggest that antidipsogenic and diuretic responses seem to be mediated via 5-HT1A receptors of the lateral-medial posterior magnocellular region of the PVN in water-deprived rats. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Physiol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Physiol, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Clin Anal, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Taubate, Taubate, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Physiol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Clin Anal, BR-14801903 Araraquara, SP, Brazil
dc.format.extent14-20
dc.identifierhttp://dx.doi.org/10.1016/j.regpep.2008.05.003
dc.identifier.citationRegulatory Peptides. Amsterdam: Elsevier B.V., v. 150, n. 1-3, p. 14-20, 2008.
dc.identifier.doi10.1016/j.regpep.2008.05.003
dc.identifier.issn0167-0115
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16247
dc.identifier.wosWOS:000260126300003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRegulatory Peptides
dc.relation.ispartofsjr0,512
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPVNen
dc.subjectWater intakeen
dc.subjectUrinary excretionen
dc.subject5-HTen
dc.subject8-OH-DPATen
dc.subjectpMPPFen
dc.titleActivation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Fisiologia e Patologia - FOAR
Artigos - Análises Clínicas - FCFAR