Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model

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dc.contributor.authorSuzuki, Selly Sayuri
dc.contributor.authorGarcez, Aguinaldo Silva
dc.contributor.authorSuzuki, Hideo
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorMoon, Won
dc.contributor.authorRibeiro, Martha Sim�es
dc.contributor.institutionNuclear and Energy Research Institute
dc.contributor.institutionS�o Leopoldo Mandic School and Dental Institute
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUCLA School of Dentistry
dc.date.accessioned2018-12-11T17:30:11Z
dc.date.available2018-12-11T17:30:11Z
dc.date.issued2016-12-01
dc.description.abstractThis study evaluated the biological effects of low-level laser therapy (LLLT) on bone remodeling, tooth displacement and root resorption, occurred during the orthodontic tooth movement. Upper first molars of a total of sixty-eight male rats were subjected to orthodontic tooth movement and euthanized on days 3, 6, 9, 14 and 21 days and divided as negative control, control and LLLT group. Tooth displacement and histomorphometric analysis were performed in all animals; scanning electron microscopy analysis was done on days 3, 6 and 9, as well as the immunohistochemistry analysis of RANKL/OPG and TRAP markers. Volumetric changes in alveolar bone were analyzed using MicroCT images on days 14 and 21. LLLT influenced bone resorption by increasing the number of TRAP-positive osteoclasts and the RANKL expression at the compression side. This resulted in less alveolar bone and hyalinization areas on days 6, 9 and 14. LLLT also induced less bone volume and density, facilitating significant acceleration of tooth movement and potential reduction in root resorption besides stimulating bone formation at the tension side by enhancing OPG expression, increasing trabecular thickness and bone volume on day 21. Taken together, our results indicate that LLLT can stimulate bone remodeling reducing root resorption in a rat model. (Figure presented.) LLLT improves tooth movement via bone formation and bone resorption in a rat model.en
dc.description.affiliationCLA – Center for Laser and Applications Nuclear and Energy Research Institute
dc.description.affiliationDepartment of Microbiology S�o Leopoldo Mandic School and Dental Institute
dc.description.affiliationDepartment of Orthodontics S�o Leopoldo Mandic School and Dental Institute
dc.description.affiliationDepartment of Basic Science and Embryology and Histology Dental School of Ara�atuba – UNESP
dc.description.affiliationSection of Orthodontics UCLA School of Dentistry
dc.description.affiliationUnespDepartment of Basic Science and Embryology and Histology Dental School of Ara�atuba – UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/06079-8
dc.format.extent1222-1235
dc.identifierhttp://dx.doi.org/10.1002/jbio.201600016
dc.identifier.citationJournal of Biophotonics, v. 9, n. 11-12, p. 1222-1235, 2016.
dc.identifier.doi10.1002/jbio.201600016
dc.identifier.issn1864-0648
dc.identifier.issn1864-063X
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-84995608758
dc.identifier.urihttp://hdl.handle.net/11449/178415
dc.language.isoeng
dc.relation.ispartofJournal of Biophotonics
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbone remodeling
dc.subjectmicroCT
dc.subjectnear infrared laser
dc.subjectOPG
dc.subjectRANKL
dc.subjectroot resorption
dc.subjectTRAP
dc.titleLow-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent modelen
dc.typeArtigo
unesp.author.lattes4408095517346846[4]
unesp.author.orcid0000-0003-4859-0583[4]

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