Synergism of crude extracts and essential oils from medicinal plants with antimicrobial drugs

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dc.contributor.authorSilva, Nathalia Cristina Cirone [UNESP]
dc.contributor.authorBarbosa, Lidiane Nunes [UNESP]
dc.contributor.authorAndrade, Bruna Fernanda Murbach Teles [UNESP]
dc.contributor.authorProbst, Isabela da Silva [UNESP]
dc.contributor.authorDoyama, Julio Toshio [UNESP]
dc.contributor.authorFernandes Junior, Ary [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:44:48Z
dc.date.available2016-04-01T18:44:48Z
dc.date.issued2013
dc.description.abstractThe emergence of resistant strains to conventional antimicrobial drugs has been constant as well as research aimed new alternatives of antibacterial agents. Therefore, considering that natural products have been an important potential source of new antimicrobial drugs, aim to verify the synergism by disk and time kill curve method between antimicrobials (extracts-Ext. and essential oils-EO) from four plant and eight antimicrobial drugs against Staphylococcus aureus and Escherichia coli strains from human specimens. The S. aures strains were highly susceptible with all plant antimicrobials (eg., 1.24 mg/ml with Vernonia polyanthes Ext. and 2.21 mg/ml with Eugenia uniflora EO for the Minimal Inhibitory Concentration-MIC). According disk method, the Bacharis dracunculifolia and V. polyanthes EO had synergism with all eight tested drugs while only Matricaria chamomilla Ext. showed synergism against S. aureus. The synergism was found with V. polyanthes and E. uniflora Ext. while M. chamomilla Ext. had antagonism against E. coli strains. By time kill curve, the bacterial growth inhibition was superior when drugs were tested alone and the synergism effect also was verified. The antagonism effect was detected only for E. coli strains and only with Ext. Results indicated the potential use of these products as coadjutants during treatment of infectious diseases.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Química e Bioquímica, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Química e Bioquímica, Botucatu, SP, Brasil
dc.format.extent189-197
dc.identifierhttps://sites.google.com/site/photonjournals/home/journal-of-antimicrobials
dc.identifier.citationJournal of Antimicrobials, v. 128, n. 1, p. 189-197, 2013.
dc.identifier.fileISSN2236-4308-2013-128-01-189-197.pdf
dc.identifier.issn2236-4308
dc.identifier.lattes1328624135976476
dc.identifier.orcid0000-0001-9456-4111
dc.identifier.urihttp://hdl.handle.net/11449/137234
dc.language.isoeng
dc.relation.ispartofJournal of Antimicrobials
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectAntimicrobial activityen
dc.subjectEssential oilsen
dc.subjectMethanolic extracten
dc.subjectMedicinal plantsen
dc.subjectS. aureusen
dc.subjectE. colien
dc.subjectP. Aeruginosaen
dc.titleSynergism of crude extracts and essential oils from medicinal plants with antimicrobial drugsen
dc.typeArtigo
unesp.author.lattes1328624135976476
unesp.author.lattes8310835825824360[6]
unesp.author.orcid0000-0001-9456-4111
unesp.author.orcid0000-0002-2744-2824[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologiapt
unesp.departmentQuímica e Bioquímicapt

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Artigos - Microbiologia e Imunologia - IBB
Artigos - Química e Bioquímica - IBB