Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats

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dc.contributor.authorZhu, Ming-lin
dc.contributor.authorZhao, Jin-ping
dc.contributor.authorCui, Ning
dc.contributor.authorGonçalves-Rizzi, Victor H. [UNESP]
dc.contributor.authorPossomato-Vieira, Jose S. [UNESP]
dc.contributor.authorNascimento, Regina A. [UNESP]
dc.contributor.authorDias-Junior, Carlos A. [UNESP]
dc.contributor.institutionWuhan University
dc.contributor.institutionRenmin Hospital of Wuhan University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:17:05Z
dc.date.available2018-12-11T17:17:05Z
dc.date.issued2017-12-01
dc.description.abstractMyeloperoxidase (MPO) is released from activated neutrophils. The inflammation in preeclampsia was found to be associated with endothelial dysfunction. We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy. Systolic and diastolic blood pressure and heart rate were measured on pregnancy days 14, 16, 18 and 20 in normal pregnant and hypertensive pregnant rats. Left and right ventricle weights, the number of viable fetuses, litter size, fetal and placenta weights were recorded on gestational day 21. Circulating and cardiac MPO activities, soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelial growth factor (VEGF) and nitric oxide (NO) were detected. The results showed increases in cardiac (left, but not right ventricle) and circulating MPO activities, and concomitantly lower number of viable fetuses, litter size, and fetal and placenta weights, and decreases in NO in hypertensive pregnant rats. Also, the increases in circulating sFlt-1 and VEGF were found in hypertensive pregnant group. In conclusion, maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia.en
dc.description.affiliationDepartment of Thoracic and Cardiovascular Surgery Zhongnan Hospital Wuhan University
dc.description.affiliationDepartment of Gastroenterology Renmin Hospital of Wuhan University
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP)
dc.format.extent904-909
dc.identifierhttp://dx.doi.org/10.1007/s11596-017-1825-6
dc.identifier.citationJournal of Huazhong University of Science and Technology - Medical Science, v. 37, n. 6, p. 904-909, 2017.
dc.identifier.doi10.1007/s11596-017-1825-6
dc.identifier.file2-s2.0-85039048560.pdf
dc.identifier.issn1672-0733
dc.identifier.scopus2-s2.0-85039048560
dc.identifier.urihttp://hdl.handle.net/11449/175687
dc.language.isoeng
dc.relation.ispartofJournal of Huazhong University of Science and Technology - Medical Science
dc.relation.ispartofsjr0,406
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjecthypertensive pregnancy
dc.subjectmyeloperoxidase
dc.subjectpreeclampsia
dc.subjectrats
dc.titleCardiac myeloperoxidase activity is elevated in hypertensive pregnant ratsen
dc.typeArtigo
unesp.author.lattes6296664642422599[7]
unesp.author.orcid0000-0002-0348-6144[7]

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