Role of natural killer cells in antitumor resistance

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dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:40Z
dc.date.available2014-05-27T11:21:40Z
dc.date.issued2005-12-01
dc.description.abstractNatural killer cells constitute a population of lymphocytes able to non-specifically destroy virus-infected and some kinds of tumor cells. Since this lytic activity was shown by non-immunized animals the phenomenon is denominated natural killer (NK) activity and contrasts with specific cytotoxicity performed by cytolytic T lymphocytes (CTLs) because it does not depends on MHC-restricted peptides recognition. In fact, the main feature of most functional receptors of NK cells (NKRs) is their ability to be inhibited by different kinds of class I MHC antigens. In the middle of the 1950's, Burnet & Thomas forged the concept of tumor immunosurveillance and NK cells can be considered one of the main figures in this phenomenon both for effector and regulatory functions. In the present review the early studies on the biology of NK cells were revisited and both their antitumor activity and dependence on the activation by cytokines are discussed.en
dc.description.affiliationDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP Universidade Estadual Paulista, Botucatu - SP
dc.description.affiliationDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP Universidade Estadual Paulista, Camp. de Rubiao Jr. s/n, Cx. p. 510, 18618-000 - Botucatu - SP
dc.description.affiliationUnespDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP Universidade Estadual Paulista, Botucatu - SP
dc.description.affiliationUnespDepartamento de Microbiologia e Imunologia Instituto de Biociências UNESP Universidade Estadual Paulista, Camp. de Rubiao Jr. s/n, Cx. p. 510, 18618-000 - Botucatu - SP
dc.format.extent127-148
dc.identifierhttp://arbs.biblioteca.unesp.br/index.php/arbs/article/view/47/46
dc.identifier.citationAnnual Review of Biomedical Sciences, v. 7, p. 127-148.
dc.identifier.file2-s2.0-32044458595.pdf
dc.identifier.issn1806-8774
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.scopus2-s2.0-32044458595
dc.identifier.urihttp://hdl.handle.net/11449/68500
dc.language.isoeng
dc.relation.ispartofAnnual Review of Biomedical Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCell activation
dc.subjectCytotoxicity
dc.subjectNatural killer
dc.subjectTumor immunology
dc.subjectbatroxobin
dc.subjectgangliotetraosylceramide
dc.subjectinterferon
dc.subjectinterleukin 12
dc.subjectinterleukin 15
dc.subjectinterleukin 21
dc.subjectinterleukin 23
dc.subjectinterleukin 4
dc.subjectinterleukin 6
dc.subjectmonoclonal antibody
dc.subjectmonoclonal antibody pk 136
dc.subjectperforin
dc.subjectrecombinant alpha interferon
dc.subjecttumor necrosis factor alpha
dc.subjectunclassified drug
dc.subjectacute myeloblastic leukemia
dc.subjectangiogenesis
dc.subjectantigen recognition
dc.subjectantineoplastic activity
dc.subjectblood clotting disorder
dc.subjectbone marrow transplantation
dc.subjectBurkitt lymphoma
dc.subjectcancer cell culture
dc.subjectcancer growth
dc.subjectcancer immunology
dc.subjectcancer immunotherapy
dc.subjectcancer infiltration
dc.subjectcancer inhibition
dc.subjectcancer patient
dc.subjectcancer resistance
dc.subjectcancer susceptibility
dc.subjectcolon carcinogenesis
dc.subjectcolon carcinoma
dc.subjectcolorectal carcinoma
dc.subjectdendritic cell
dc.subjectdiarrhea
dc.subjecteffector cell
dc.subjecthost resistance
dc.subjecthuman
dc.subjectimmunosurveillance
dc.subjectliver metastasis
dc.subjectlung disease
dc.subjectlung metastasis
dc.subjectlymphokine activated killer cell
dc.subjectmelanoma cell
dc.subjectmetastasis inhibition
dc.subjectnatural killer T cell
dc.subjectnonhuman
dc.subjectreview
dc.subjectskin toxicity
dc.subjectT lymphocyte subpopulation
dc.subjectthrombocytopenia
dc.subjectAnimalia
dc.titleRole of natural killer cells in antitumor resistanceen
dc.typeArtigo
dcterms.licensehttp://arbs.biblioteca.unesp.br/index.php/arbs/about
unesp.author.lattes8845835550637809
unesp.author.orcid0000-0002-4292-3298
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB