Piperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case report

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dc.contributor.authorNeves, Precil Diego Miranda de Menezes [UNESP]
dc.contributor.authorFreitas, Fernanda Moreira de [UNESP]
dc.contributor.authorKojima, Christiane Akemi [UNESP]
dc.contributor.authorCarmello, Beatriz Leone [UNESP]
dc.contributor.authorBazan, Rodrigo [UNESP]
dc.contributor.authorBarretti, Pasqual [UNESP]
dc.contributor.authorMartin, Luis Cuadrado [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:42:56Z
dc.date.available2016-04-01T18:42:56Z
dc.date.issued2015
dc.description.abstractAntibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are thebeta-lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67-year-old woman inregular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia,which was initially treated with cefepime. Two days after treatment, she presented dysarthria, lefthemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acutelesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced bypiperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomographyshowed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysissessions, the patient completely recovered from neurological manifestations. The patient presentedsequentially neurotoxicity caused by two beta-lactams antibiotics. This report meant to alertclinicians that these antibiotics have dangerous neurological effects in chronic kidney diseasepatients.en
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu
dc.format.extent143-145
dc.identifierhttp://dx.doi.org/10.1111/hdi.12194
dc.identifier.citationHemodialysis International, v. 19, n. 1, p. 143-145, 2015.
dc.identifier.doi10.1111/hdi.12194
dc.identifier.issn1492-7535
dc.identifier.lattes7862086981190726
dc.identifier.lattes5496411983893479
dc.identifier.lattes7862086981190726
dc.identifier.lattes5496411983893479
dc.identifier.lattes7862086981190726
dc.identifier.lattes5496411983893479
dc.identifier.lattes4923203168446615
dc.identifier.orcid0000-0003-4979-4836
dc.identifier.urihttp://hdl.handle.net/11449/136852
dc.language.isoeng
dc.relation.ispartofHemodialysis International
dc.relation.ispartofjcr1.237
dc.relation.ispartofsjr0,554
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectChronic kidney diseaseen
dc.subjectHemodialysisen
dc.subjectNeurotoxicityen
dc.subjectPiperacillin/tazobactamen
dc.titlePiperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case reporten
dc.typeArtigo
unesp.author.lattes5496411983893479
unesp.author.lattes7862086981190726
unesp.author.lattes5496411983893479[6]
unesp.author.lattes7862086981190726
unesp.author.lattes4923203168446615
unesp.author.orcid0000-0003-4979-4836[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médicapt
unesp.departmentNeurologia, Psicologia e Psiquiatriapt

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Artigos - Clínica Médica - FMB
Artigos - Neurologia, Psicologia e Psiquiatria - FMB