Enzymatic synthesis of enantiopure alcohols: current state and perspectives

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dc.contributor.authorChen, Bi-Shuang
dc.contributor.authorRibeiro de Souza, Fayene Zeferino [UNESP]
dc.contributor.institutionSun Yat-Sen University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:31:24Z
dc.date.available2019-10-06T15:31:24Z
dc.date.issued2019-01-01
dc.description.abstractEnantiomerically pure alcohols, as key intermediates, play an essential role in the pharmaceutical, agrochemical and chemical industries. Among the methods used for their production, biotechnological approaches are generally considered a green and effective alternative due to their mild reaction conditions and remarkable enantioselectivity. An increasing number of enzymatic strategies for the synthesis of these compounds has been developed over the years, among which seven primary methodologies can be distinguished as follows: (1) enantioselective water addition to alkenes, (2) enantioselective aldol addition, (3) enantioselective coupling of ketones with hydrogen cyanide, (4) asymmetric reduction of carbonyl compounds, (5) (dynamic) kinetic resolution of racemates, (6) enantioselective hydrolysis of epoxides, and (7) stereoselective hydroxylation of unactivated C-H bonds. Some recent reviews have examined these approaches separately; however, to date, no review has included all the above mentioned strategies. The aim of this mini-review is to provide an overview of all seven enzymatic strategies and draw conclusions on the effect of each approach.en
dc.description.affiliationSchool of Marine Sciences Sun Yat-Sen University
dc.description.affiliationSouth China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Sun Yat-Sen University
dc.description.affiliationDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista UNESP
dc.description.affiliationUnespDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista UNESP
dc.format.extent2102-2115
dc.identifierhttp://dx.doi.org/10.1039/C8RA09004A
dc.identifier.citationRSC Advances, v. 9, n. 4, p. 2102-2115, 2019.
dc.identifier.doi10.1039/C8RA09004A
dc.identifier.issn2046-2069
dc.identifier.scopus2-s2.0-85060317612
dc.identifier.urihttp://hdl.handle.net/11449/187282
dc.language.isoeng
dc.relation.ispartofRSC Advances
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleEnzymatic synthesis of enantiopure alcohols: current state and perspectivesen
dc.typeResenha

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