Evaluation of area contaminated by wood treatment activities: genetic markers in the environment and in the child population

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dc.contributor.authorCoronas, Mariana Vieira
dc.contributor.authorRocha, Jocelita Aparecida Vaz
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorVargas, Vera Maria Ferrão
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionFundação Estadual de Proteção Ambiental Henrique Luís Roessler (FEPAM)
dc.contributor.institutionInstituto Nacional de Genética Médica Populacional (INAGEMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:31:44Z
dc.date.available2015-12-07T15:31:44Z
dc.date.issued2015
dc.description.abstractWood preservation activities and related compounds are a problem since these areas have major environmental contamination liabilities which compromise the health of the surrounding population and the integrity of ecological processes. The present study evaluated an area influenced by soil contamination arising from the activities of a deactivated wood treatment plant. The presence and effect of mutagenic compounds in environmental samples were used as markers of exposure together with the evaluation biomarkers of genetic damage in children. Organic extracts from samples of public source water and from fine atmospheric particulate matter (PM2.5) were evaluated for mutagenic potential using the Salmonella/microsome assay. Children living in the area surrounding the plant were analyzed for genetic damage assessed by the comet assay in lymphocytes and micronucleus test (MN) in lymphocytes and oral mucosa and compared to a group living in an area outside the preferential quadrant of atmospheric dispersion and in opposition to the drainage at the site. The mutagenic effect and PAHs concentrations found were similar to studies that evaluated intensely occupied urban areas and those under industrial influence. The MN frequencies in lymphocytes and binucleated cells in the oral mucosa were significantly higher in the risk group. No significant differences were observed in the other genetic damage biomarkers evaluated. The presence of pollutants with a mutagenic and carcinogenic effect on the PM2.5 and the increased in some biomarkers indicate that the population is potentially exposed to substances capable of causing adverse health effects and atmospheric airborne is a possible exposure route.en
dc.description.affiliationPrograma de Pós-graduação em Ecologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil
dc.description.affiliationPrograma de Pesquisas Ambientais, Fundação Estadual de Proteção Ambiental Henrique Luís Roessler (FEPAM), Porto Alegre, RS, Brasil
dc.description.affiliationInstituto Nacional de Genética Médica Populacional (INAGEMP), Rio de Janeiro, RJ, Brasil
dc.description.affiliationDepartamento de Patologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationUnespDepartamento de Patologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCNPq: 573993/2008-4
dc.description.sponsorshipIdCNPq: 555187/2006-3
dc.format.extent1207-1215
dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2015.09.084
dc.identifier.citationChemosphere, v. 144, p. 1207-1215, 2015.
dc.identifier.doi10.1016/j.chemosphere.2015.09.084
dc.identifier.issn1879-1298
dc.identifier.lattes5051118752980903
dc.identifier.pubmed26465966
dc.identifier.urihttp://hdl.handle.net/11449/131117
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofChemosphere
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectComet assayen
dc.subjectMicronucleusen
dc.subjectPahsen
dc.subjectPm2.5en
dc.subjectSalmonella/microsomeen
dc.subjectWood treatmenten
dc.titleEvaluation of area contaminated by wood treatment activities: genetic markers in the environment and in the child populationen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.lattes5051118752980903
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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