Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?

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dc.contributor.authorFernandes, Glaura S. A.
dc.contributor.authorGerardin, Daniela C. C.
dc.contributor.authorAssumpcao, Thaiane A. [UNESP]
dc.contributor.authorCampos, Kleber E. [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.authorKempinas, Wilma D. G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T13:35:25Z
dc.date.available2014-05-20T13:35:25Z
dc.date.issued2011-07-01
dc.description.abstractDiabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the alpha-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Grad Program Cellular & Struct Biol, Inst Biol, BR-13083862 Campinas, SP, Brazil
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Physiol Sci, Londrina UEL, BR-86051980 Londrina, PR, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent983-991
dc.identifierhttp://www.if-pan.krakow.pl/pjp/pdf/2011/4_983_ab.pdf
dc.identifier.citationPharmacological Reports. Krakow: Polish Acad Sciences Inst Pharmacology, v. 63, n. 4, p. 983-991, 2011.
dc.identifier.issn1734-1140
dc.identifier.urihttp://hdl.handle.net/11449/12183
dc.identifier.wosWOS:000297530600015
dc.language.isoeng
dc.publisherPolish Acad Sciences Inst Pharmacology
dc.relation.ispartofPharmacological Reports
dc.relation.ispartofjcr2.787
dc.relation.ispartofsjr0,773
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectvitamin Cen
dc.subjectvitamin Een
dc.subjecthyperglycemiaen
dc.subjecttestosteroneen
dc.subjectvas deferensen
dc.subjectnorepinephrineen
dc.subjectmale reproductive systemen
dc.subjectmale raten
dc.titleCan vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?en
dc.typeArtigo
dcterms.licensehttp://www.if-pan.krakow.pl/pjp/note.html
dcterms.rightsHolderPolish Acad Sciences Inst Pharmacology
unesp.author.orcid0000-0002-2112-5123[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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