Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina

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dc.contributor.authorCruz, A. D.
dc.contributor.authorBatista, G. C.M.
dc.contributor.authorModolo, J. R. [UNESP]
dc.contributor.authorGottschalk, A. F. [UNESP]
dc.contributor.authorLopes, C. A.M.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:55:59Z
dc.date.available2022-04-28T19:55:59Z
dc.date.issued1998-08-01
dc.description.abstractThe antimicrobial activity of danofloxacin, a new 4-fluoroquinolone for exclusive use in Veterinary Medicine, was compared in vitro with other seven drugs against 200 strains of Staphylococcus aureus isolated from bovine mastitis. By using the antimicrobial disk diffusion method (Bauer-Kirby), the results showed that the imipenem (100%), trimethoprim/sulfamethoxazole (98.9%), cefuroxime (97.3%) were the most effective drugs taking into consideration the percentuals of sensitiveness. However, considering the percentuals of the moderately sensitive strains, danofloxacin emerged as the third most active drug. The antimicrobial dilution susceptibility test used to study the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of danofloxacin, characterized its significative antimicrobial activity by showing a close relationship between both concentrations (MIC90% = 0.18μg/ml - MBC90% = 0.23μg/ml), as well as a MIC/MBC ratio of 1:1 and 1:2 for most of tested strains.en
dc.description.affiliationDepto. de Higiene Vet. e Saude Pub. Faculdade de Med. Vet. Zootecnia UNESP, Caixa Postal, 510, CEP 18618-000 - Botucatu, SP
dc.description.affiliationUnespDepto. de Higiene Vet. e Saude Pub. Faculdade de Med. Vet. Zootecnia UNESP, Caixa Postal, 510, CEP 18618-000 - Botucatu, SP
dc.format.extent369-373
dc.identifier.citationArquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 50, n. 4, p. 369-373, 1998.
dc.identifier.issn0102-0935
dc.identifier.scopus2-s2.0-0041171319
dc.identifier.urihttp://hdl.handle.net/11449/224337
dc.language.isopor
dc.relation.ispartofArquivo Brasileiro de Medicina Veterinaria e Zootecnia
dc.sourceScopus
dc.subjectBovine
dc.subjectDanofloxacin
dc.subjectMastitis
dc.subjectStaphylococcus aureus
dc.titleAtividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovinapt
dc.title.alternativeAntimicrobial activity of danofloxacin and seven other drugs against Staphylococcus aureus from bovine mastitisen
dc.typeArtigo

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