A dinâmica da resposta do tecido subcutâneo para associação de microorganismos com o extrato de araçá (Psidium cattleianum): Uma análise microscópica e edemogênica

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dc.contributor.authorMachado, Alessandra Cury
dc.contributor.authorRuviére, Denise Belúcio [UNESP]
dc.contributor.authorNovais, Renata Zoccal [UNESP]
dc.contributor.authorBueno, Carlos Roberto Emerenciano [UNESP]
dc.contributor.authorJardim Junior, Élerson Gaetti [UNESP]
dc.contributor.authorde Oliveira, Rodrigo Cardoso
dc.contributor.authorDezan Junior, Elói [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:15:01Z
dc.date.available2018-12-11T17:15:01Z
dc.date.issued2017-01-01
dc.description.abstractObjective: To evaluate in vivo tissue reaction to the extract of araçá (Psidium cattleianum) associated with inactivated microorganisms. Material and Methods: A 0.1 mL suspension was used containing Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Enterococcus faecalis, Peptostreptococcus micros, and Porphyromonas endodontalis, which were inactivated by heat and mixed into a 1.0 mL saline (control group), an aqueous solution, or a hydroalcoholic extract of araçá. Eighteen male rats (Rattus norvegiccus) under general anesthesia received 0.2 mL of 1% intravenous Evans blue. Thirty minutes later, 0.1 mL of one of the associations was injected into the animals’ dorsal region. The animals were euthanized after 3 and 6 hours, and the materials obtained were placed in formamide for 72 hours then analyzed in a spectrophotometer (λ=630 ηm). For the morphological analysis, 30 rats received polyethylene tubes implants with the extracts or the saline with the associations in the dorsal region and euthanized after 7 and 30 days to be analyzed according to an inflammation cell score. Results: No significant difference (p>0.05) was observed in the edema among groups. The optical microscopy results showed a repair in the 30-day-period, which was higher when compared to the 7-day-period (p<0.0001). Nevertheless, in the 7-day-period, the hydroalcoholic extract presented a significant response compared to the aqueous extract (p=0.05) and a trend for better results than the control group. Conclusion: The aqueous and hydroalcoholic araçá extracts associated with inactivated microorganisms showed similar responses to control, indicating no interference on the toxic effects of the bacterial components in tissue repair.en
dc.description.affiliationDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo
dc.description.affiliationDepartment of Restorative Dentistry Araçatuba School of Dentistry UNESP Univ. Estadual Paulista
dc.description.affiliationDepartment of Pathology Araçatuba School of Dentistry UNESP Univ. Estadual Paulista
dc.description.affiliationUnespDepartment of Restorative Dentistry Araçatuba School of Dentistry UNESP Univ. Estadual Paulista
dc.description.affiliationUnespDepartment of Pathology Araçatuba School of Dentistry UNESP Univ. Estadual Paulista
dc.format.extent93-101
dc.identifierhttp://dx.doi.org/10.14295/bds.2017.v20i2.1408
dc.identifier.citationBrazilian Dental Science, v. 20, n. 2, p. 93-101, 2017.
dc.identifier.doi10.14295/bds.2017.v20i2.1408
dc.identifier.issn2178-6011
dc.identifier.lattes4605992512582464
dc.identifier.lattes8813777272581972
dc.identifier.orcid0000-0002-6568-7734
dc.identifier.orcid0000-0002-5699-6578
dc.identifier.scopus2-s2.0-85029883625
dc.identifier.urihttp://hdl.handle.net/11449/175255
dc.language.isoeng
dc.relation.ispartofBrazilian Dental Science
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnaerobic bacteria
dc.subjectEdema
dc.subjectInflammation
dc.subjectPlant extracts
dc.subjectPsidium
dc.titleA dinâmica da resposta do tecido subcutâneo para associação de microorganismos com o extrato de araçá (Psidium cattleianum): Uma análise microscópica e edemogênicapt
dc.title.alternativeThe dynamics of subcutaneous tissue response to microorganisms associated with the extract of araçá (Psidium cattleianum): An edemogenic and microscopic analysisen
dc.typeArtigo
unesp.author.lattes4605992512582464[5]
unesp.author.lattes8813777272581972[7]
unesp.author.orcid0000-0002-6568-7734[5]
unesp.author.orcid0000-0002-5699-6578[7]

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Artigos - Odontologia Restauradora - FOA
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