Effects of Resistance Exercise on Slow-Twitch Soleus Muscle of Infarcted Rats

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dc.contributor.authorSouza, Lidiane Moreira [UNESP]
dc.contributor.authorGomes, Mariana Janini
dc.contributor.authorBrandao, Bruna Brasil
dc.contributor.authorPagan, Luana Urbano [UNESP]
dc.contributor.authorGatto, Mariana [UNESP]
dc.contributor.authorDamatto, Felipe Cesar [UNESP]
dc.contributor.authorRodrigues, Eder Anderson [UNESP]
dc.contributor.authorPontes, Thierres Hernani Dias [UNESP]
dc.contributor.authorBorim, Patricia Aparecida [UNESP]
dc.contributor.authorFernandes, Ana Angelica Henrique [UNESP]
dc.contributor.authorMurata, Gilson Masahiro
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorAzevedo, Paula Schmidt [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionTexas AM University
dc.contributor.institutionHarvard Medical School
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T13:44:16Z
dc.date.available2023-07-29T13:44:16Z
dc.date.issued2023-02-01
dc.description.abstractAlthough current guidelines recommend resistance exercise in combination with aerobic training to increase muscle strength and prevent skeletal muscle loss during cardiac remodeling, its effects are not clear. In this study, we evaluated the effects of resistance training on cardiac remodeling and the soleus muscle in long-term myocardial infarction (MI) rats. Methods: Three months after MI induction, male Wistar rats were assigned to Sham (n = 14), MI (n = 9), and resistance exercised MI (R-MI, n = 13) groups. The rats trained three times a week for 12 weeks on a climbing ladder. An echocardiogram was performed before and after training. Protein expression of the insulin-like growth factor (IGF)-1/protein kinase B (Akt)/rapamycin target complex (mTOR) pathway was analyzed by Western blot. Results: Mortality rate was higher in MI than Sham; in the R-MI group, mortality rate was between that in MI and Sham and did not differ significantly from either group. Exercise increased maximal load capacity without changing cardiac structure and left ventricular function in infarcted rats. Infarction size did not differ between infarcted groups. Catalase activity was lower in MI than Sham and glutathione peroxidase lower in MI than Sham and R-MI. Protein expression of p70S6K was lower in MI than Sham and p-FoxO3 was lower in MI than Sham and R-MI. Energy metabolism did not differ between groups, except for higher phosphofrutokinase activity in R-MI than MI. Conclusion: Resistance exercise is safe and increases muscle strength regardless structural and functional cardiac changes in myocardial-infarcted rats. This exercise modality attenuates soleus glycolytic metabolism changes and improves the expression of proteins required for protein turnover and antioxidant response.en
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School Sao Paulo State University UNESP, SP
dc.description.affiliationDepartment of Kinesiology and Sport Management Texas AM University
dc.description.affiliationSection of Integrative Physiology and Metabolism Joslin Diabetes Center Harvard Medical School
dc.description.affiliationDepartment of Chemistry and Biochemistry Institute of Biosciences Sao Paulo State University UNESP, SP
dc.description.affiliationLaboratory of Medical Investigation (LIM-29) Clinic Medical Department University of Sao Paulo Medical School, SP
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School Sao Paulo State University UNESP, SP
dc.description.affiliationUnespDepartment of Chemistry and Biochemistry Institute of Biosciences Sao Paulo State University UNESP, SP
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 153424/2018-4
dc.description.sponsorshipIdCNPq: 308557/2018-2
dc.description.sponsorshipIdCNPq: 310876/2018-4
dc.description.sponsorshipIdCAPES: 88882.432904/2019-01
dc.identifierhttp://dx.doi.org/10.3390/antiox12020291
dc.identifier.citationAntioxidants, v. 12, n. 2, 2023.
dc.identifier.doi10.3390/antiox12020291
dc.identifier.issn2076-3921
dc.identifier.scopus2-s2.0-85149211449
dc.identifier.urihttp://hdl.handle.net/11449/248445
dc.language.isoeng
dc.relation.ispartofAntioxidants
dc.sourceScopus
dc.subjectechocardiogram
dc.subjectheart failure
dc.subjectleft ventricular function
dc.subjectmyocardial infarction
dc.subjectphysical training
dc.subjectrat
dc.titleEffects of Resistance Exercise on Slow-Twitch Soleus Muscle of Infarcted Ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-9726-3901[1]
unesp.author.orcid0000-0002-3115-0795[5]
unesp.author.orcid0000-0003-3383-5410[11]

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