Effect of allopurinol in the course of adriamycin induced nephropathy

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dc.contributor.authorCarvalho, Maria Fernanda C. [UNESP]
dc.contributor.authorViero, Rosa Marlene [UNESP]
dc.contributor.authorSoares, Vitor A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:43Z
dc.date.available2014-05-27T11:19:43Z
dc.date.issued1999-04-06
dc.description.abstractThe role of superoxide in adriamycin-induced nephropathy (single dose; i.v. 3 mg/kg) has been studied by blocking superoxide synthesis through the administration of allopurinol (500 mg/L in drinking water). In Experiment I (EI), allopurinol administration was started 3 days prior to nephropathy induction and continued until day 14. In Experiment II (EII) allopurinol administration was started 2 weeks after nephropathy induction and was maintained until the end of the experiment (26 weeks). Affected glomeruli frequency and tubulointerstitial lesion index (TILI) were determined at Weeks 2 and 4 (EI) and Week 26 (EII). In EI, and 24 h mean proteinuria in the nephrotic control group (NCG-I) differed from that of the treated nephrotic group (TNG-I) at Week 1 (TNG = 33.3 ± 6.39 mg/24 h; NCG = 59.8 ± 6.3 mg/24 h; p < 0.05) and 2 (NCG-I = 80.0 ± 17.5 mg/24h; TNG-I = 49.1 ± 8.4 mg/24 h; p < 0.05). No glomerular alterations were observed and TILI medians were not different in both nephrotic groups at week 2 (NCG-I = 1+: TNG = 1+) and 4 (NCG = 4+; TNG = 4+). In EII, NCG-II and TNG-II presented different 24 h proteinuria values only at Week 6, (136.91 ± 22.23 mg/24 h ad 72.66 ± 10.72 mg/24 h, respectively; p < 0.05). Between nephrotic groups, there was no statistical difference in the median of affected glomeruli (CNG-II = 56%; TNG-II = 48% and TILI (NCG-II = 8+; TNG-II = 9+). Thus, allopurinol was associated with a transient reduction in proteinuria and it did not alter the progression of the nephropathy.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School-UNESP, Botucatu, SP
dc.description.affiliationDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, P.O. Box 584, CEP: 18618-970 Botucatu, SP
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School-UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Clinica Medica Faculdade de Medicina de Botucatu UNESP, P.O. Box 584, CEP: 18618-970 Botucatu, SP
dc.format.extent147-154
dc.identifierhttp://dx.doi.org/10.3109/08860229909066979
dc.identifier.citationRenal Failure, v. 21, n. 2, p. 147-154, 1999.
dc.identifier.doi10.3109/08860229909066979
dc.identifier.issn0886-022X
dc.identifier.lattes1453564171333848
dc.identifier.scopus2-s2.0-0033003520
dc.identifier.urihttp://hdl.handle.net/11449/65759
dc.identifier.wosWOS:000079149000003
dc.language.isoeng
dc.relation.ispartofRenal Failure
dc.relation.ispartofjcr1.440
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdriamycin nephropathy
dc.subjectAllopurinol
dc.subjectGlomerulosclerosis
dc.subjectProteinuria
dc.subjectSuperoxide
dc.subjectallopurinol
dc.subjectdoxorubicin
dc.subjectfree radical
dc.subjectsuperoxide
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug induced disease
dc.subjectelectron microscopy
dc.subjectglomerulosclerosis
dc.subjectintravenous drug administration
dc.subjectkidney biopsy
dc.subjectkidney disease
dc.subjectnephrotoxicity
dc.subjectpriority journal
dc.subjectproteinuria
dc.subjectpurine metabolism
dc.subjectAntineoplastic Agents
dc.subjectBiopsy
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectDoxorubicin
dc.subjectFollow-Up Studies
dc.subjectFree Radical Scavengers
dc.subjectGlomerulosclerosis, Focal Segmental
dc.subjectKidney Glomerulus
dc.subjectKidney Tubules
dc.subjectNephritis, Interstitial
dc.subjectRandom Allocation
dc.subjectRats, Wistar
dc.titleEffect of allopurinol in the course of adriamycin induced nephropathyen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes1453564171333848
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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