Cytotoxicity of Active Ingredients Extracted from Plants of the Brazilian "Cerrado"

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dc.contributor.authorSoares, Veronica C. G.
dc.contributor.authorBonacorsi, Cibele [UNESP]
dc.contributor.authorAndrela, Alana L. B.
dc.contributor.authorBortoloti, Ligia V.
dc.contributor.authorde Campos, Stepheny C.
dc.contributor.authorFagundes, Fabio H. R.
dc.contributor.authorPiovani, Marcio
dc.contributor.authorCotrim, Camila A.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorToyama, Marcos H. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUnianchieta
dc.contributor.institutionUniv Paulista
dc.date.accessioned2014-05-20T15:31:57Z
dc.date.available2014-05-20T15:31:57Z
dc.date.issued2011-07-01
dc.description.abstractCytotoxicity assays arc needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian "cerrado". The viability was assayed with the neutral red uptake assay in Mac Coy cells after 24h of exposition. The dose evaluated was 50 mu g/mu L. The test substances were: cinnamic acid, p-coumaric acid, chlorogenic acid, syringic acid, vannilic acid, homogentisic acid, scandenin, palustric acid, diosgenin, cabraleone. Studies of cytotoxicity demonstrated that all active compounds evaluated have low toxicity in vitro. The substances showed cell viability above 60% for the concentration used. However, the cinnamic acid, sacandenin and palustric acid showed highest toxicity with a 50% reduction in cell viability for the dose of 50 mu g/mu L. Cytotoxic screening results are useful to estimate the best concentrations of those compounds with potential anti-inflammatory without their cause cell death.en
dc.description.affiliationUniv Estadual Campinas, Inst Biol, BR-13083862 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Microbiol, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Chem, BR-14801970 São Paulo, Brazil
dc.description.affiliationUnianchieta, Dept Pharm, BR-13207270 São Paulo, Brazil
dc.description.affiliationUniv Paulista, Dept Pharm, BR-13214525 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biol, BR-11330150 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Microbiol, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Chem, BR-14801970 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biol, BR-11330150 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent983-984
dc.identifier.citationNatural Product Communications. Westerville: Natural Products Inc, v. 6, n. 7, p. 983-984, 2011.
dc.identifier.issn1934-578X
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/40961
dc.identifier.wosWOS:000292492300015
dc.language.isoeng
dc.publisherNatural Products Inc
dc.relation.ispartofNatural Product Communications
dc.relation.ispartofjcr0.809
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNatural productsen
dc.subjectCytotoxicityen
dc.subjectBrazilian Cerradoen
dc.titleCytotoxicity of Active Ingredients Extracted from Plants of the Brazilian "Cerrado"en
dc.typeArtigo
dcterms.licensehttp://www.naturalproduct.us/content/copyright_transfer.pdf
dcterms.rightsHolderNatural Products Inc
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[9]
unesp.author.orcid0000-0002-9176-5767[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept

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Artigos - Ciências Biológicas - São Vicente