Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly

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dc.contributor.authorMendonça, Fabio Henrique Boarini Pacheco
dc.contributor.authorSantos, Silvana Soléo Ferreira dos
dc.contributor.authorFaria, Ivan da Silva de
dc.contributor.authorGonçalves e Silva, Célia Regina
dc.contributor.authorJorge, Antonio Olavo Cardoso [UNESP]
dc.contributor.authorLeão, Mariella Vieira Pereira
dc.contributor.institutionUNITAU - University of Taubaté
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:57Z
dc.date.available2014-05-27T11:26:57Z
dc.date.issued2012-09-01
dc.description.abstractImbalance in the resident microbiota may promote the growth of opportunistic microorganisms, such as yeasts of Candida genus and the development of diseases, especially in aged people. This study evaluated whether the consumption of the probiotic Yakult LB® (Lactobacillus casei and Bifidobacterium breve) was able to influence on the specific immunological response against Candida and on the presence of these yeasts in the oral cavity of 42 healthy aged individuals. Saliva samples were collected before and after the probiotic use for 30 days, 3 times a week. The samples were plated in Dextrose Saboraud Agar with chloramphenicol, the colony-forming units (CFU/mL) were counted and the Candida species were identified. Anti-Candida IgA analysis was conducted using the ELISA technique. ANOVA and Student's t-test were used for normally distributed data and the Wilcoxon test was used for data with non-normal distribution (α=0.05). The results showed a statistically significant reduction (p<0.05) in Candida prevalence (from 92.9% to 85.7%), in CFU/mL counts of Candida and in the number of non-albicans species after consumption of the probiotic. Immunological analysis demonstrated a significant increase (p<0.05) in anti-Candida IgA levels. In conclusion, probiotic bacteria reduced Candida numbers in the oral cavity of the elderly and increased specific secretory immune response against these yeasts, suggesting its possible use in controlling oral candidosis.en
dc.description.affiliationBasic Institute of Biosciences UNITAU - University of Taubaté, Taubaté, SP
dc.description.affiliationSão José dos Campos Dental School Universidade Estadual Paulista (UNESP), São José dos Campos, SP
dc.description.affiliationUnespSão José dos Campos Dental School Universidade Estadual Paulista (UNESP), São José dos Campos, SP
dc.format.extent534-538
dc.identifierhttp://dx.doi.org/10.1590/S0103-64402012000500011
dc.identifier.citationBrazilian Dental Journal, v. 23, n. 5, p. 534-538, 2012.
dc.identifier.doi10.1590/S0103-64402012000500011
dc.identifier.file2-s2.0-84872370984.pdf
dc.identifier.issn0103-6440
dc.identifier.issn1806-4760
dc.identifier.lattes0053567153623569
dc.identifier.scieloS0103-64402012000500011
dc.identifier.scopus2-s2.0-84872370984
dc.identifier.urihttp://hdl.handle.net/11449/73539
dc.language.isoeng
dc.relation.ispartofBrazilian Dental Journal
dc.relation.ispartofsjr0,476
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCandida
dc.subjectElderly
dc.subjectGeriatrics
dc.subjectProbiotics
dc.titleEffects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderlyen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bdj/paboutj.htm
unesp.author.lattes0053567153623569[5]
unesp.author.orcid0000-0002-1747-6158[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT