Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats

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dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorSinzato, S. [UNESP]
dc.contributor.authorCampos, Kleber Eduardo de [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.date.accessioned2014-05-20T13:35:53Z
dc.date.available2014-05-20T13:35:53Z
dc.date.issued2011-12-08
dc.description.abstractEthnopharmacological relevance: Morus nigra, commonly known as black mulberry, is widely used in Brazilian folk medicine for the diabetes treatment.Aim of this study: To evaluate the effect of Morus nigra aqueous extract treatment on maternal lipid and oxidative stress profile, reproductive outcomes, and also fetal anomaly incidence from diabetic and non-diabetic rats.Materials and methods: Diabetes was induced by streptozotocin (40 mg/kg) in virgin female Wistar rats. Morus nigra leaf aqueous extract (400 mg/kg) was administered from day 0 to 20 of pregnancy. At day 21 of pregnancy, all rats were anesthetized and killed to obtain blood samples and maternal-fetal data.Results and conclusion: After treatment with Morus nigra extract, non-diabetic and diabetic rats presented no glycemic changes. Fetuses from diabetic dams, regardless of Morus nigra treatment, were small for pregnancy age. In diabetic dams, plant treatment caused reduced MDA, cholesterol, triglycerides and VLDL levels, and decreased placental index and weight as compared to diabetic group. The fetuses from diabetic rats treated with Morus nigra extract had lower frequency of skeletal and visceral anomalies as compared to diabetic group. Thus, Morus nigra leaf aqueous extract failed to control hyperglycemia in diabetic rats. However, Morus nigra treatment had antioxidant effect, contributing to reduce incidence of internal anomalies in offspring from diabetic dams. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Unesp, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, São Paulo, Brazil
dc.description.affiliationMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Barra do Garcas, Mato Grosso, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Unesp, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipResearch Support Center (RSC) of the Botucatu Medical School - São Paulo State
dc.description.sponsorshipIdFAPESP: 03/01654-2
dc.format.extent691-696
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2011.09.044
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 138, n. 3, p. 691-696, 2011.
dc.identifier.doi10.1016/j.jep.2011.09.044
dc.identifier.fileWOS000298897800007.pdf
dc.identifier.issn0378-8741
dc.identifier.lattes0679387622604743
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12346
dc.identifier.wosWOS:000298897800007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMorus nigraen
dc.subjectDiabetesen
dc.subjectPregnancyen
dc.subjectOxidative stressen
dc.subjectReproductive outcomeen
dc.subjectAnomalyen
dc.titleEffect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0679387622604743
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0003-4761-4336[2]
unesp.author.orcid0000-0002-7003-9643[6]
unesp.author.orcid0000-0002-4753-3264[1]
unesp.author.orcid0000-0002-9227-832X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB