SFlt-1 and IP-10 in women with early-onset preeclampsia

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dc.contributor.authorOliveira, Leandro Gustavo de [UNESP]
dc.contributor.authorCâmara, Niels Olsen S.
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorMoron, Antonio F.
dc.contributor.authorSass, Nelson
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital e Maternidade Vila Nova Cachoeirinha
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:30Z
dc.date.available2014-05-27T11:25:30Z
dc.date.issued2011-04-01
dc.description.abstractIntense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia. © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationObstetrics Department Universidade Federal de São Paulo, Rua Napoleão de Barros, 875, Vila Clementino, São Paulo 04024-002
dc.description.affiliationLaboratory of Immunobiology of Transplantation Universidade de São Paulo
dc.description.affiliationLaboratory of Clinical and Experimental Investigation Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo
dc.description.affiliationObstetrics Department Universidade Estadual de São Paulo, Botucatu
dc.description.affiliationUnespObstetrics Department Universidade Estadual de São Paulo, Botucatu
dc.format.extent129-131
dc.identifierhttp://dx.doi.org/10.1016/j.preghy.2011.02.002
dc.identifier.citationPregnancy Hypertension, v. 1, n. 2, p. 129-131, 2011.
dc.identifier.doi10.1016/j.preghy.2011.02.002
dc.identifier.issn2210-7789
dc.identifier.lattes8499437381595614
dc.identifier.lattes0720794820325913
dc.identifier.lattes6486557387397806
dc.identifier.scopus2-s2.0-79952655899
dc.identifier.urihttp://hdl.handle.net/11449/72349
dc.language.isoeng
dc.relation.ispartofPregnancy Hypertension
dc.relation.ispartofjcr2.011
dc.relation.ispartofsjr1,205
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAngiogenic factors
dc.subjectInflammation
dc.subjectIP-10
dc.subjectPlGF
dc.subjectPreeclampsia
dc.subjectsFlt-1
dc.subjectgamma interferon inducible protein 10
dc.subjectplacental growth factor
dc.subjectvasculotropin receptor 1
dc.subjectadult
dc.subjectchemoluminescence
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytometry
dc.subjectfemale
dc.subjecthuman
dc.subjecthypothesis
dc.subjectimmunoassay
dc.subjectinflammation
dc.subjectpathogenesis
dc.subjectpreeclampsia
dc.subjectprotein blood level
dc.titleSFlt-1 and IP-10 in women with early-onset preeclampsiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes0720794820325913
unesp.author.lattes8499437381595614
unesp.author.lattes6486557387397806
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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