Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite

Página do item simplificado
dc.contributor.authorDe Gobbi, Juliana Irani Fratucci [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorBeltz, Terry G.
dc.contributor.authorJohnson, Ralph F.
dc.contributor.authorThunhorst, Robert L.
dc.contributor.authorJohnson, Alan Kim
dc.contributor.institutionUniv Iowa
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:58Z
dc.date.available2014-05-20T13:45:58Z
dc.date.issued2008-08-01
dc.description.abstractThe inflation of an intravascular balloon positioned at the superior vena cava and right atrial junction (SVC-RAJ) reduces sodium or water intake induced by various experimental procedures (e.g. sodium depletion; hypovolaemia). In the present study we investigated if the stretch induced by a balloon at this site inhibits a rapid onset salt appetite, and if this procedure modifies the pattern of immunohistochemical labelling for Fos protein (Fos-ir) in the brain. Male Sprague-Dawley rats with SVC-RAJ balloons received a combined treatment of furosemide (Furo; 10 mg (kg bw)(-1)) plus a low dose of the angiotensin-converting enzyme inhibitor captopril (Cap; 5 mg (kg bw)(-1)). Balloon inflation greatly decreased the intake of 0.3 M NaCl for as long as the balloon was inflated. Balloon inflation over a 3 h period following Furo-Cap treatment decreased Fos-ir in the organum vasculosum of the lamina terminalis and the subfornical organ and increased Fos-ir in the lateral parabrachial nucleus and caudal ventrolateral medulla. The effect of balloon inflation was specific for sodium intake because it did not affect the drinking of diluted sweetened condensed milk. Balloon inflation and deflation also did not acutely change mean arterial pressure. These results suggest that activity in forebrain circumventricular organs and in hindbrain putative body fluid/cardiovascular regulatory regions is affected by loading low pressure mechanoreceptors at the SVC-RAJ, a manipulation that also attenuates salt appetite.en
dc.description.affiliationUniv Iowa, Dept Psychol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Dept Integrat Physiol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Dept Pharmacol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA
dc.description.affiliationUNESP, Dept Physiol, Biosci Inst, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Physiol, Biosci Inst, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent3719-3729
dc.identifierhttp://dx.doi.org/10.1113/jphysiol.2008.151282
dc.identifier.citationJournal of Physiology-london. Malden: Wiley-blackwell, v. 586, n. 15, p. 3719-3729, 2008.
dc.identifier.doi10.1113/jphysiol.2008.151282
dc.identifier.issn0022-3751
dc.identifier.urihttp://hdl.handle.net/11449/16227
dc.identifier.wosWOS:000258100500013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Physiology-london
dc.relation.ispartofjcr4.540
dc.relation.ispartofsjr2,051
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleRight atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetiteen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.orcid0000-0001-5845-0475[1]
unesp.author.orcid0000-0003-1167-4441[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Fisiologia - IBB
Artigos - Fisiologia e Patologia - FOAR