Role of junctional epithelium in maintaining dento-gingival adhesion and periodontal health

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dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorHolcroft, James
dc.contributor.authorMcCulloch, Christopher A.
dc.contributor.authorGanss, Bernhard
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionLatin American Institute of Dental Research and Education (ILAPEO)
dc.contributor.institutionUniversity of Toronto
dc.date.accessioned2023-07-29T16:13:33Z
dc.date.available2023-07-29T16:13:33Z
dc.date.issued2023-01-01
dc.description.abstractThe dento-gingival junction comprises multiple epithelia including the junctional epithelium (JE), which is the most coronally-located structural element of the dento-gingival junction that demarcates external from internal periodontal environments. After tooth eruption into the oral cavity, a specialized basal lamina is formed that provides firm attachment of the JE to the enamel. This attachment prevents microbial species and oral debris from entering subjacent periodontal tissues. Here we discuss the expression of certain JE adhesion molecules and enamel proteins that maintain the health of the dento-gingival junction but that are perturbed in the pathogenesis of periodontitis. We also consider how evolutionary processes have influenced the development of the JE as a specialized adhesion that is well-suited for protection of the dento-gingival junction. A detailed understanding of the biology of the JE will deepen current models of dento-gingival adhesion, potentially clarify inter-patient variability of susceptibility to periodontitis and help to identify new roles of enamel proteins in periodontal regeneration.en
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationLatin American Institute of Dental Research and Education (ILAPEO)
dc.description.affiliationDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationFaculty of Dentistry University of Toronto
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3389/fdmed.2023.1144537
dc.identifier.citationFrontiers in Dental Medicine, v. 4.
dc.identifier.doi10.3389/fdmed.2023.1144537
dc.identifier.issn2673-4915
dc.identifier.scopus2-s2.0-85159007008
dc.identifier.urihttp://hdl.handle.net/11449/249945
dc.language.isoeng
dc.relation.ispartofFrontiers in Dental Medicine
dc.sourceScopus
dc.subjectdentogingival adhesion
dc.subjectenamel proteins
dc.subjectjunctional epithelium
dc.subjectperiodontal tissues
dc.subjectperiodontitis
dc.subjectreview
dc.titleRole of junctional epithelium in maintaining dento-gingival adhesion and periodontal healthen
dc.typeArtigo

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Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Ciências Básicas - FOA