Strain pattern and T-wave alterations are predictors of mortality and poor neurologic outcome following stroke

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dc.contributor.authorBraga, Gabriel P. [UNESP]
dc.contributor.authorGonçalves, Renato S. [UNESP]
dc.contributor.authorMinicucci, Marcos F. [UNESP]
dc.contributor.authorBazan, Rodrigo [UNESP]
dc.contributor.authorZornoff, Leonardo A. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:11:14Z
dc.date.available2020-12-12T02:11:14Z
dc.date.issued2020-06-01
dc.description.abstractBackground: Stroke is associated with electrocardiogram (ECG) abnormalities. However, the role of strain pattern as predictor of poor neurologic outcome and mortality after stroke has not yet been demonstrated. Hypothesis: ECG abnormalities, with a particular focus on ST-segment changes, are predictors of mortality and neurologic disability 90 days after stroke. Methods: Patients with up to 24 hours of stroke were prospectively recruited. An ECG was taken at the time of admission. The patients' clinical evolution was evaluated during hospitalization and after discharge by means of a prescheduled return in 90 days. The degree of disability was measured by the modified Rankin scale (mRs). In relation to the mRs, patients were divided into those with scores from 0 to 2 and those with scores equal to or greater than 3 at the end of the observation period. Results: Of the 112 patients studied, 29 (25.8%) died during the study period. Patients who died presented higher National Institute of Health Stroke Scale and mRs scores on admission, elevated biomarkers of myocardial necrosis, and abnormalities on the ECG. The prevalence of ECG abnormalities was 63%. A logistic regression model showed that strain pattern and T-wave alterations were predictors of mortality (odds ratio [OR]: 12.970, 95% confidence interval [CI]: 1.519-110.723, P =.019; OR: 3.873, 95% CI: 1.135-13.215, P =.031, respectively) and mRs at 90 days (OR: 12.557, 95% CI: 1.671-94.374, P =.014; OR: 15.970, 95% CI: 3.671-69.479, P <.001, respectively) after stroke, adjusted by sex, age, stroke subtype, entrance NIH, previous mRs score, and stroke thrombolysis. Conclusion: Strain pattern and T-wave alterations were predictors of mortality and poor neurologic outcome 90 days after stroke.en
dc.description.affiliationBotucatu Medical School Neurology Department São Paulo State University (Unesp)
dc.description.affiliationBotucatu Medical School Internal Medicine Department São Paulo State University (Unesp)
dc.description.affiliationUnespBotucatu Medical School Neurology Department São Paulo State University (Unesp)
dc.description.affiliationUnespBotucatu Medical School Internal Medicine Department São Paulo State University (Unesp)
dc.format.extent568-573
dc.identifierhttp://dx.doi.org/10.1002/clc.23348
dc.identifier.citationClinical Cardiology, v. 43, n. 6, p. 568-573, 2020.
dc.identifier.doi10.1002/clc.23348
dc.identifier.issn1932-8737
dc.identifier.issn0160-9289
dc.identifier.scopus2-s2.0-85086606530
dc.identifier.urihttp://hdl.handle.net/11449/200613
dc.language.isoeng
dc.relation.ispartofClinical Cardiology
dc.sourceScopus
dc.subjectelectrocardiogram
dc.subjectmortality
dc.subjectneurologic disability
dc.subjectoutcomes
dc.subjectprediction
dc.subjectstroke
dc.titleStrain pattern and T-wave alterations are predictors of mortality and poor neurologic outcome following strokeen
dc.typeArtigo
unesp.author.orcid0000-0002-9831-8820[5]

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Artigos - Neurologia, Psicologia e Psiquiatria - FMB
Artigos - Clínica Médica - FMB