Hypocholesterolaemic effect of rat-administered oral doses of the isolated 7S globulins from cowpeas and adzuki beans

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dc.contributor.authorFerreira, Ederlan S.
dc.contributor.authorAmaral, Ana Lucia S. [UNESP]
dc.contributor.authorDemonte, Aureluce [UNESP]
dc.contributor.authorZanelli, Cleslei F. [UNESP]
dc.contributor.authorCapraro, Jessica
dc.contributor.authorDuranti, Marcello
dc.contributor.authorNeves, Valdir Augusto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversità degli Studi di Milano
dc.date.accessioned2016-01-28T16:56:13Z
dc.date.available2016-01-28T16:56:13Z
dc.date.issued2015
dc.description.abstractThe role of seed proteins, especially soyabean 7S globulins, in controlling dyslipidaemia is widely acknowledged. Amino acid sequence homology among the proteins of this family could reflect similar biological functions in other species. The aim of the present study was to unveil a hypolipidaemic effect of the 7S globulins from cowpeas (7S-C) and adzuki beans (7S-A), administered orally to rats fed a hypercholesterolaemic (HC; high cholesterol and TAG) diet for 28 d. A total of forty-five rats were divided into five groups (nine rats per group): (1) standard (STD) diet; (2) HC diet; (3) HC diet + 7S-C (300 mg/kg per d); (4) HC diet + 7S-A (300 mg/kg per d); and (5) HC diet + simvastatin (SVT; 50 mg/kg per d), as a control. Significant decreases in food intake and final body weight of rats receiving HC + 7S-C and HC + 7S-A diets compared with groups fed the HC and STD diets were observed. Significant decreases in serum total and non-HDL-cholesterol of 7S-C, 7S-A and SVT groups were also observed. HDL-cholesterol levels increased in the 7S-C, 7S-A and SVT groups, while hepatic cholesterol and TAG concentrations were significantly lower than in the HC diet group for the 7S-C-supplemented group only. Faecal excretions of fat and cholesterol in HC diet groups were considerably higher in animals consuming the 7S globulins. The results show that cowpea and adzuki bean 7S globulins promote cholesterol-decreasing effects in hypercholesterolaemic rats even at low dosages, as already observed for other legume seed storage proteins of this family. This main effect is discussed in relation to the possible mechanisms of action.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, RODOVIA ARARAQUARA-JAU KM 01, CAMPUS UNIVERSITARIO, CEP 14801-902, SP, Brasil
dc.description.affiliationDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via G. Celoria, 2, 20133, Milan, Italy
dc.description.affiliationDepartment of Bromatological Analysis, School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Road, 147, 40170-115, Salvador, BA, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Department of Food and Nutrition
dc.description.affiliationUnespDepartment of Biological Sciences School of Pharmaceutical Sciences, São Paulo State University, Rodovia Araraquara – Jaú, km 1, 14801-902, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2009/11511-0
dc.description.sponsorshipIdFAPESP: 2011/11779-3
dc.format.extent1-9
dc.identifierhttp://dx.doi.org/10.1017/jns.2014.70
dc.identifier.citationJournal of Nutritional Science, v. 4, n. e7, p. 1-9, 2015.
dc.identifier.doi10.1017/jns.2014.70
dc.identifier.issn2048-6790
dc.identifier.lattes4031319519910419
dc.identifier.lattes5269969767845353
dc.identifier.lattes1525665408900195
dc.identifier.orcid0000-0001-7831-1149
dc.identifier.urihttp://hdl.handle.net/11449/133697
dc.language.isoeng
dc.relation.ispartofJournal of Nutritional Science
dc.relation.ispartofsjr0,984
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectVigna unguiculataen
dc.subjectVigna angularisen
dc.subject7S globulinsen
dc.subjectCholesterolen
dc.subjectRatsen
dc.titleHypocholesterolaemic effect of rat-administered oral doses of the isolated 7S globulins from cowpeas and adzuki beansen
dc.typeArtigo
unesp.author.lattes5269969767845353
unesp.author.lattes4031319519910419
unesp.author.lattes1525665408900195[4]
unesp.author.orcid0000-0001-7831-1149[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Alimentos e Nutrição - FCFAR
Artigos - Ciências Biológicas - FCFAR