Potential Use of Phenolic Acids as Anti-Candida Agents: A Review

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dc.contributor.authorTeodoro, Guilherme R. [UNESP]
dc.contributor.authorEllepola, Kassapa
dc.contributor.authorSeneviratne, Chaminda J.
dc.contributor.authorKoga-Ito, Cristiane Y. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNatl Univ Singapore
dc.date.accessioned2018-11-26T16:19:02Z
dc.date.available2018-11-26T16:19:02Z
dc.date.issued2015-12-21
dc.description.abstractThere has been a sharp rise in the occurrence of Candida infections and associated mortality over the last few years, due to the growing body of immunocompromised population. Limited number of currently available antifungal agents, undesirable side effects and toxicity, as well as emergence of resistant strains pose a considerable clinical challenge for the treatment of candidiasis. Therefore, molecules that derived from natural sources exhibiting considerable antifungal properties are a promising source for the development of novel anti-candidal therapy. Phenolic compounds isolated from natural sources possess antifungal properties of interest. Particularly, phenolic acids have shown promising in vitro and in vivo activity against Candida species. However, studies on their mechanism of action alone or in synergism with known antifungals are still scarce. This review attempts to discuss the potential use, proposed mechanisms of action and limitations of the phenolic acids in anti-candidal therapy.en
dc.description.affiliationUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Oral Biopathol Grad Program, Sao Jose Dos Campos, Brazil
dc.description.affiliationNatl Univ Singapore, Fac Dent, Oral Sci, Singapore 117548, Singapore
dc.description.affiliationUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Dept Environm Engn, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Biopathol Grad Program, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Oral Biopathol Grad Program, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Dept Environm Engn, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose dos Campos Inst Sci & Technol, Biopathol Grad Program, Sao Jose Dos Campos, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNational University of Singapore
dc.description.sponsorshipNUS
dc.description.sponsorshipIdFAPESP: 2013/0037-1
dc.description.sponsorshipIdFAPESP: 2012/16805-5
dc.description.sponsorshipIdNUS: R-221-000-064-133
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2015.01420
dc.identifier.citationFrontiers In Microbiology. Lausanne: Frontiers Media Sa, v. 6, 11 p., 2015.
dc.identifier.doi10.3389/fmicb.2015.01420
dc.identifier.fileWOS000366991500001.pdf
dc.identifier.issn1664-302X
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.urihttp://hdl.handle.net/11449/161074
dc.identifier.wosWOS:000366991500001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Microbiology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCandida
dc.subjectphenolic acids
dc.subjectphenolic compounds
dc.subjectantifungal effect
dc.subjectsynergism
dc.titlePotential Use of Phenolic Acids as Anti-Candida Agents: A Reviewen
dc.typeArtigo
dcterms.rightsHolderFrontiers Media Sa
unesp.author.lattes6543563161403421[4]
unesp.author.orcid0000-0003-3806-9807[2]
unesp.author.orcid0000-0002-2416-2173[4]

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