Lack of chemopreventive effects of ginger on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats

Página do item simplificado
dc.contributor.authorDias, M. C.
dc.contributor.authorSpinardi-Barbisan, ALT
dc.contributor.authorRodrigues, MAM
dc.contributor.authorde Camargo, JLV
dc.contributor.authorTeran, E.
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:36:55Z
dc.date.available2014-05-20T13:36:55Z
dc.date.issued2006-06-01
dc.description.abstractGinger (Zingiber officinale Roscoe) has been proposed as a promising candidate for cancer prevention. Its modifying potential on the process of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) was investigated in male Wistar rats using the aberrant crypt foci (ACF) assay. Five groups were studied: Groups 1-3 were given four s.c. injections of DMH (40 mg/kg b.w.) twice a week, during two weeks, whereas Groups 4 and 5 received similar injections of EDTA solution (DMH vehicle). After DMH-initiation, the animals were fed a ginger extract mixed in the basal diet at 0.5% (Group 2) and 1.0% (Groups 3 and 4) for 10 weeks. All rats were killed after 12 weeks and the colons were analyzed for ACF formation and crypt multiplicity. The rates of cell proliferation and apoptosis were also evaluated in epithelial colonic crypt cells. Dietary consumption of ginger at both dose levels did not induce any toxicity in the rats, but ginger meal at 1% decreased significantly serum cholesterol levels (p < 0.038). Treatment with ginger did not suppress ACF formation or the number of crypts per ACF in the DMH-treated group. Dietary ginger did not significantly change the proliferative or apoptosis indexes of the colonic crypt cells induced by DMH. Thus, the present results did not confirm a chemopreventive activity of ginger on colon carcinogenesis as analyzed by the ACF bioassay and by the growth kinetics of the colonic mucosa. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Med, Dept PatholTOXICAN, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationGrp Ctr Flora, BR-18603970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Med, Dept PatholTOXICAN, BR-18618000 Botucatu, SP, Brazil
dc.format.extent877-884
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2005.11.015
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 44, n. 6, p. 877-884, 2006.
dc.identifier.doi10.1016/j.fct.2005.11.015
dc.identifier.issn0278-6915
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/12712
dc.identifier.wosWOS:000238552600012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdimethylhydrazinept
dc.subjectaberrant crypt focipt
dc.subjectcolon carcinogenesispt
dc.subjectgingerpt
dc.subjectchemopreventionpt
dc.titleLack of chemopreventive effects of ginger on colon carcinogenesis induced by 1,2-dimethylhydrazine in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0003-3833-4172[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Morfologia - IBB
Artigos - Patologia - FMB