ENDOCRINE INTERACTION BETWEEN ZINC AND PROLACTIN - AN INTERPRETATIVE REVIEW

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dc.contributor.authorBrandaoneto, J.
dc.contributor.authorMadureira, G.
dc.contributor.authorMendonca, B. B.
dc.contributor.authorBloise, W.
dc.contributor.authorCastro, AVB
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:55Z
dc.date.available2014-05-20T15:21:55Z
dc.date.issued1995-08-01
dc.description.abstractZinc plays a very important role in animal and human metabolism. Nowadays, it is one of the most extensively studied trace element, since its sphere of action has been demonstrated to be very broad. From the biochemical standpoint, it controls more than 300 different enzymes, many of them involved with intermediary metabolism, DNA and RNA synthesis, gene expression, and immunocompetence. It also plays a significant role in hormonal homeostasis, since it can interact with almost all hormones. Zn2+ is closely related to the thyroid and steroid hormones, insulin, parathormone, and pituitary hormones, particularly prolactin (PRL). Zn2+ can inhibit PRL secretion within a range of physiologically and pharmacologically relevant concentrations. This property has raised the possibility of clinical applications of zinc. In this article, we review the Literature on the subject in an attempt to provide a comprehensible general view.en
dc.description.affiliationUNIV SAO PAULO,DEPT MED,DIV ENDOCRINOL,BR-05508 SAO PAULO,BRAZIL
dc.format.extent139-149
dc.identifierhttp://dx.doi.org/10.1007/BF02788963
dc.identifier.citationBiological Trace Element Research. Totowa: Humana Press Inc., v. 49, n. 2-3, p. 139-149, 1995.
dc.identifier.doi10.1007/BF02788963
dc.identifier.issn0163-4984
dc.identifier.urihttp://hdl.handle.net/11449/32988
dc.identifier.wosWOS:A1995RU91000006
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.ispartofjcr2.361
dc.relation.ispartofsjr0,719
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectZINCpt
dc.subjectPROLACTIN SYNTHESIS, STORAGE, AND SECRETIONpt
dc.subjectPROLACTINOMApt
dc.subjectNORMAL INDIVIDUALSpt
dc.titleENDOCRINE INTERACTION BETWEEN ZINC AND PROLACTIN - AN INTERPRETATIVE REVIEWen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderHumana Press Inc
unesp.author.orcid0000-0003-1762-1084[3]

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