Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

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dc.contributor.authorde Almeida, Amanda Cosmo [UNESP]
dc.contributor.authorTorquetti, Carolina [UNESP]
dc.contributor.authorFerreira, Patrícia Osório [UNESP]
dc.contributor.authorFernandes, Richard Perosa [UNESP]
dc.contributor.authordos Santos, Everton Carvalho [UNESP]
dc.contributor.authorKogawa, Ana Carolina [UNESP]
dc.contributor.authorCaires, Flávio Junior [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T00:59:53Z
dc.date.available2020-12-12T00:59:53Z
dc.date.issued2020-03-01
dc.description.abstractThis article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using differential scanning calorimetry (DSC), thermogravimetry and simultaneous differential thermal analysis (TG-DTA), infrared spectroscopy (IR), and powder X-ray diffractometry (PXRD). Using these thermal, spectroscopic and diffractometric methods it was possible to verify the formation of the cocrystals, either with or without the addition of ethanol. Additionally, binary phase diagrams, constructed from the data of the DSC curves, confirmed the formation of the cocrystals and their stoichiometry; 1:1 (mol/mol) was determined as the optimal stoichiometric ratio. Furthermore, the formed cocrystals were capable of improving the aqueous solubility of the bioactive agent used in this study.en
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationSchool of Sciences São Paulo State University (UNESP)
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1016/j.tca.2019.178346
dc.identifier.citationThermochimica Acta, v. 685.
dc.identifier.doi10.1016/j.tca.2019.178346
dc.identifier.issn0040-6031
dc.identifier.scopus2-s2.0-85074834942
dc.identifier.urihttp://hdl.handle.net/11449/198125
dc.language.isoeng
dc.relation.ispartofThermochimica Acta
dc.sourceScopus
dc.subjectCiprofloxacin
dc.subjectCocrystal
dc.subjectMechanochemical synthesis
dc.subjectSolubility study
dc.subjectThermal analysis
dc.titleCocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility studyen
dc.typeArtigo

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