The sympathetic adrenomedullary system, but not the hypothalamic-pituitary-adrenal axis, participates in aorta adaptive response to stress: nitric oxide involvement

Página do item simplificado
dc.contributor.authorNavarro-Oliveira, C. M.
dc.contributor.authorVassilieff, V. S.
dc.contributor.authorCordellini, S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.date.accessioned2014-05-20T13:49:03Z
dc.date.available2014-05-20T13:49:03Z
dc.date.issued2000-10-02
dc.description.abstractStress induced a decrease in the reactivity of the aorta to noradrenaline (NA), as a consequence of an endothelial nitric oxide (NO) system hyperactivity. The main characteristic of the stress response is activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic adrenomedullary (SA) system. The participation of the HPA axis and SA system in the decreased reactivity to NA in the aorta of rats exposed to 4-h immobilization was investigated. Concentration-response relationships for NA were obtained in the aorta, with and without endothelium, isolated from normal and stressed rats, following these procedures: (1) in the absence and presence of L-NAME; (2) after adrenalectomy (ADX) or not, in the absence or presence of L-NAME; (3) ADX rats treated or not with corticosterone; (4) ADX associated with stress; and (5) treated or not with reserpine. The reactivity of aorta without endothelium was unaffected by the procedures. The reactivity of aorta with endothelium was decreased by either stress or ADX. This effect was reversed by both L-NAME and corticosterone. ADX did not potentiate the decrease in the aorta reactivity induced by stress. Reserpine did not change the reactivity of aorta with endothelium from normal rats, but prevented the decrease in reactivity induced by stress. It is concluded that the HPA axis participates in endothelium-dependent modulation of aorta reactivity in normal conditions and that thr SA system participates in hyperactivity of the endothelial NO-system induced by stress, which is responsible for the decreased aorta reactivity to NA. (C) 2000 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Oeste Paulista, Fac Pharm & Biochem, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, CEATOX, BR-01405 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, CEATOX, BR-01405 São Paulo, Brazil
dc.format.extent140-147
dc.identifierhttp://dx.doi.org/10.1016/S1566-0702(00)00157-0
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 83, n. 3, p. 140-147, 2000.
dc.identifier.doi10.1016/S1566-0702(00)00157-0
dc.identifier.issn1566-0702
dc.identifier.lattes5616488317690037
dc.identifier.urihttp://hdl.handle.net/11449/17474
dc.identifier.wosWOS:000089195800005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofjcr2.605
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsympathetic adrenomedullary systempt
dc.subjecthypothalamic-pituitary-adrenal axispt
dc.subjectstresspt
dc.subjectreactivity of rat aortapt
dc.subjectendotheliumpt
dc.subjectnitric oxidept
dc.titleThe sympathetic adrenomedullary system, but not the hypothalamic-pituitary-adrenal axis, participates in aorta adaptive response to stress: nitric oxide involvementen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5616488317690037
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Farmacologia - IBB
Botucatu - CEATOX - Centro de Assistência Toxicológica