Genomic data as the hitchhiker's guide to cattle adaptation: tracking the milestones of past selection in the bovine genome

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dc.contributor.authorUtsunomiya, Yuri T. [UNESP]
dc.contributor.authorPérez O'Brien, Ana M.
dc.contributor.authorSonstegard, Tad S.
dc.contributor.authorSölkner, Johann
dc.contributor.authorGarcia, José F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionDivision of Livestock Sciences, Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
dc.contributor.institutionAnimal Genomics and Improvement Laboratory, Agricultural Research Service, United States Department of Agriculture Beltsville, MA, USA.
dc.date.accessioned2015-12-07T15:33:40Z
dc.date.available2015-12-07T15:33:40Z
dc.date.issued2015
dc.description.abstractThe bovine species have witnessed and played a major role in the drastic socio-economical changes that shaped our culture over the last 10,000 years. During this journey, cattle hitchhiked on human development and colonized the world, facing strong selective pressures such as dramatic environmental changes and disease challenge. Consequently, hundreds of specialized cattle breeds emerged and spread around the globe, making up a rich spectrum of genomic resources. Their DNA still carry the scars left from adapting to this wide range of conditions, and we are now empowered with data and analytical tools to track the milestones of past selection in their genomes. In this review paper, we provide a summary of the reconstructed demographic events that shaped cattle diversity, offer a critical synthesis of popular methodologies applied to the search for signatures of selection (SS) in genomic data, and give examples of recent SS studies in cattle. Then, we outline the potential and challenges of the application of SS analysis in cattle, and discuss the future directions in this field.en
dc.description.affiliationDepartamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP) Jaboticabal, São Paulo, Brazil.
dc.description.affiliationDivision of Livestock Sciences, Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
dc.description.affiliationAnimal Genomics and Improvement Laboratory, Agricultural Research Service, United States Department of Agriculture Beltsville, MA, USA.
dc.description.affiliationDepartamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP) Jaboticabal, São Paulo, Brazil ; Laboratório de Bioquímica e Biologia Molecular Animal, Departamento de Apoio, Saúde e Produção Animal, Faculdade de Medicina Veterinária de Araçatuba, Universidade Estadual Paulista (UNESP) Araçatuba, São Paulo, Brazil.
dc.description.affiliationUnespDepartamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP) Jaboticabal, São Paulo, Brazil.
dc.description.affiliationUnespDepartamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP) Jaboticabal, São Paulo, Brazil ; Laboratório de Bioquímica e Biologia Molecular Animal, Departamento de Apoio, Saúde e Produção Animal, Faculdade de Medicina Veterinária de Araçatuba, Universidade Estadual Paulista (UNESP) Araçatuba, São Paulo, Brazil.
dc.format.extent36
dc.identifierhttp://dx.doi.org/10.3389/fgene.2015.00036
dc.identifier.citationFrontiers In Genetics, v. 6, p. 36, 2015.
dc.identifier.doi10.3389/fgene.2015.00036
dc.identifier.filePMC4322753.pdf
dc.identifier.issn1664-8021
dc.identifier.pmcPMC4322753
dc.identifier.pubmed25713583
dc.identifier.urihttp://hdl.handle.net/11449/131306
dc.language.isoeng
dc.publisherFrontiers In Genetics
dc.relation.ispartofFrontiers In Genetics
dc.relation.ispartofjcr4.151
dc.relation.ispartofsjr2,274
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.subjectBos indicusen
dc.subjectBos taurusen
dc.subjectAdaptationen
dc.subjectPositive selectionen
dc.subjectSingle nucleotide polymorphismen
dc.titleGenomic data as the hitchhiker's guide to cattle adaptation: tracking the milestones of past selection in the bovine genomeen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Medicina Veterinária Preventiva e Reprodução Animal - FCAV
Artigos - Apoio, Produção e Saúde Animal - FMVA