Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies

Página do item simplificado
dc.contributor.authorKeita, Hady
dc.contributor.authorSantos, Cleydson Breno Rodrigues dos
dc.contributor.authorRamos, Matheus Merces
dc.contributor.authorPadilha, Elias Carvalho [UNESP]
dc.contributor.authorSerafim, Rodolfo Bortolozo
dc.contributor.authorCastro, Andres Navarrete
dc.contributor.authorAmado, Jesus Rafael Rodriguez
dc.contributor.authorSilva, Gabriel Monteiro da
dc.contributor.authorFerreira, Irlon Maciel
dc.contributor.authorGiuliatti, Silvana
dc.contributor.authorCarvalho, Jose Carlos Tavares
dc.contributor.institutionUniv Fed Amapa
dc.contributor.institutionUniv Sierra
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Nacl Autonoma Mexico
dc.date.accessioned2020-12-10T19:49:33Z
dc.date.available2020-12-10T19:49:33Z
dc.date.issued2020-02-12
dc.description.abstractThe objectives of this study were to extract and purify Bixin from the seeds of Bixa orellana and to evaluate its hypoglycemic activity in vivo, as well as, to conduct an in silico study of selectivity on peroxisome proliferator-activated receptors via molecular docking and molecular dynamics simulations. Oral administration of Bixin (10 mg/kg) significantly reduced their glucose level that was alloxan-induced diabetic rats. Bixin showed in silico selectivity on peroxisome proliferator-activated receptors (PPARs), particularly by the peroxisome proliferator-activated receptor gamma (PPAR gamma), which supports the hypoglycemic activity of Bixin. From the results obtained, it can be inferred that Bixin presents hypoglycemic characteristics, which was confirmed by the results obtained from the in vivo and in silico tests. Bixin may act by other pathways to control blood glucose and thus it is possible that it presents a different toxicity profile than troglitazone, rosiglitazone and pioglitazone. However, more studies on the activity and toxicity of Bixin are needed to evaluate for further clinical use.en
dc.description.affiliationUniv Fed Amapa, Dept Biol Sci & Hlth, Lab Drugs Discovery, Macapa, Brazil
dc.description.affiliationUniv Sierra, Div Postgrade, Ixtlan De Juarez, Mexico
dc.description.affiliationUniv Fed Amapa, Dept Biol Sci & Hlth, Lab Modeling & Computat Chem, Macapa, Brazil
dc.description.affiliationUniv Fed Amapa, Res Grp Biocatalysis & Apllied Organ Synth, Macapa, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Nat Act Principles & Toxicol, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Cellular & Mol Biol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil
dc.description.affiliationUniv Nacl Autonoma Mexico, Fac Chem, Dept Pharm, Lab Pharmacol Nat Prod, Mexico City, DF, Mexico
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Bioinformat Grp, Dept Genet, Ribeirao Preto, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Nat Act Principles & Toxicol, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipProcad Amazonia
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: PNPD/20130076-14001012005P1
dc.description.sponsorshipIdProcad Amazonia: Auxpe - 1723/2018
dc.description.sponsorshipIdCNPq: 407768/2013-0
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1080/07391102.2020.1724567
dc.identifier.citationJournal Of Biomolecular Structure & Dynamics. Philadelphia: Taylor & Francis Inc, 12 p., 2020.
dc.identifier.doi10.1080/07391102.2020.1724567
dc.identifier.issn0739-1102
dc.identifier.urihttp://hdl.handle.net/11449/196582
dc.identifier.wosWOS:000513979000001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal Of Biomolecular Structure & Dynamics
dc.sourceWeb of Science
dc.subjectBixin
dc.subjecthypoglycemia
dc.subjectPPAR gamma
dc.subjectin vivo
dc.subjectin silico
dc.titleAssessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studiesen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.orcid0000-0001-7574-6219[7]
unesp.author.orcid0000-0002-9665-7597[8]
unesp.author.orcid0000-0002-7520-6420[10]

Arquivos

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR