Effects of intrauterine malnutrition on brain free amino acids of young rats, after nutritional recovery during lactation period

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dc.contributor.authorTrindade, C. E P
dc.contributor.authorDe Nobrega, F. J.
dc.contributor.authorTonete, S. S Q
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-26T22:13:17Z
dc.date.available2014-05-26T22:13:17Z
dc.date.issued1984-01-01
dc.description.abstractThe effect of protein-calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α-aminobutyric acids were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.en
dc.format.extent795-800
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/6502380
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition, v. 3, n. 5, p. 795-800, 1984.
dc.identifier.issn0277-2116
dc.identifier.scopus2-s2.0-0021159961
dc.identifier.urihttp://hdl.handle.net/11449/63656
dc.language.isoeng
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.relation.ispartofjcr2.752
dc.relation.ispartofsjr1,376
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectamino acid
dc.subjectanimal experiment
dc.subjectbrain
dc.subjectbreast
dc.subjectcentral nervous system
dc.subjectdiagnosis
dc.subjectkwashiorkor
dc.subjectlactation
dc.subjectmalnutrition
dc.subjectnervous system
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectprenatal development
dc.subjectrat
dc.subjectAmino Acids
dc.subjectAmino Acids, Essential
dc.subjectAnimal
dc.subjectAnimals, Suckling
dc.subjectBrain
dc.subjectDietary Proteins
dc.subjectEnergy Intake
dc.subjectFemale
dc.subjectLactation
dc.subjectNutrition Disorders
dc.subjectOrgan Weight
dc.subjectPlacenta Diseases
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.titleEffects of intrauterine malnutrition on brain free amino acids of young rats, after nutritional recovery during lactation perioden
dc.typeArtigo

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