Involvement of major components from sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis

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dc.contributor.authorGoncalves, Amanda Costa [UNESP]
dc.contributor.authorGeraldo Maia, Danielle Cardoso [UNESP]
dc.contributor.authorFerreira, Lucas Souza [UNESP]
dc.contributor.authorSilva Monnazzi, Luis Gustavo [UNESP]
dc.contributor.authorAlegranci, Pamela [UNESP]
dc.contributor.authorPolesi Placeres, Marisa Campos [UNESP]
dc.contributor.authorBatista-Duharte, Alexander [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T20:55:16Z
dc.date.available2015-10-21T20:55:16Z
dc.date.issued2015-02-01
dc.description.abstractSporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall major components over the cytosolic oligo-merization domain (NOD)-like receptors, important regulators of inflammation and responsible for the maturation of IL-1 beta and IL-18, whose functions are dependents of the caspase-1 activation, that can participate of inflammasome. It was evaluated the percentage of activation of caspase-1, the production of IL-1 beta, IL-18, IL-17, IFN-gamma and nitric oxide in a Balb/c model of S. schenckii infection. It was observed a decreased activity of caspase-1 during the fourth and sixth weeks of infection accompanied by reduced secretion of the cytokines IL-1 beta, IL-18 and IL-17 and high production of nitric oxide. IFN-gamma levels were elevated during the entire time course of infection. This temporal reduction in caspase-1 activity coincides exactly with the reported period of fungal burden associated with a transitory immunosuppression induced by this fungus and detected in similar infection models. These results indicate the importance of interaction between caspase-1, cytokines IL-1 beta and IL-18 in the host defense against S. schenckii infection, suggesting a participation the inflammasome in this response.en
dc.description.affiliationSao Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipForeigner Visiting Professor Program
dc.description.sponsorshipIdFAPESP: 2013/03190-5
dc.description.sponsorshipIdForeigner Visiting Professor Program: 07610130
dc.format.extent21-30
dc.identifierhttp://link.springer.com/article/10.1007%2Fs11046-014-9810-0
dc.identifier.citationMycopathologia, v. 179, n. 1-2, p. 21-30, 2015.
dc.identifier.doi10.1007/s11046-014-9810-0
dc.identifier.issn0301-486X
dc.identifier.lattes1730146818754269
dc.identifier.urihttp://hdl.handle.net/11449/129359
dc.identifier.wosWOS:000349528700003
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCytokinesen
dc.subjectCaspase-1en
dc.subjectNitric oxideen
dc.subjectSporothrix schenckiien
dc.titleInvolvement of major components from sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1730146818754269
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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