POTENTIAL MOLECULAR TARGETS FOR ANTITUBERCULOSIS DRUG DISCOVERY

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dc.contributor.authorSantos Fernandes, Guilherme Felipe dos [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.authorSantos, Jean Leandro dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-28T15:38:53Z
dc.date.available2018-11-28T15:38:53Z
dc.date.issued2017-06-01
dc.description.abstractTuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide in the coming years. Nevertheless, the increasing number of multidrug-resistant (MDR-TB) and extensive-drug resistance (XDR-TB) strains, and the ineffectiveness of the current treatment in latent tuberculosis are challenges to be overcome. In this review, we will demonstrate the recent advances in the tuberculosis drug discovery, focusing the research of new molecular targets in the Mycobacterium tuberculosis. Among the promising targets described herein, we highlight those, which act in different pathways in the mycobacteria, such as energy metabolism, cell wall biosynthesis, DNA synthesis, iron metabolism and transport through membranes. Furthermore, bioactive compounds discovered using phenotypic assays screening and validated through genetic approaches are also presented.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800060 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800060 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, Brazil
dc.format.extent572-585
dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20170016
dc.identifier.citationQuimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 40, n. 5, p. 572-585, 2017.
dc.identifier.doi10.21577/0100-4042.20170016
dc.identifier.fileS0100-40422017000500572.pdf
dc.identifier.issn0100-4042
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scieloS0100-40422017000500572
dc.identifier.urihttp://hdl.handle.net/11449/165665
dc.identifier.wosWOS:000405413000013
dc.language.isopor
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofQuimica Nova
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectmedicinal chemistry
dc.subjecttuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectmolecular targets
dc.subjectnew drugs
dc.titlePOTENTIAL MOLECULAR TARGETS FOR ANTITUBERCULOSIS DRUG DISCOVERYen
dc.typeResenha
dcterms.rightsHolderSoc Brasileira Quimica
unesp.author.lattes9734333607975413[2]
unesp.author.orcid0000-0003-4141-0455[2]

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Artigos - Fármacos e Medicamentos - FCFAR