Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy

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dc.contributor.authorSoares, Milena Botelho Pereira
dc.contributor.authorLima, Ricardo Santana de
dc.contributor.authorRocha, Leonardo Lima
dc.contributor.authorVasconcelos, Juliana Fraga
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorSantos, Ricardo Ribeiro dos
dc.contributor.authorIacobas, Sanda
dc.contributor.authorGoldenberg, Regina Coeli
dc.contributor.authorIacobas, Dumitru Andrei
dc.contributor.authorTanowitz, Herbert Bernard
dc.contributor.authorCarvalho, Antonio Carlos Campos de
dc.contributor.authorSpray, David Conover
dc.contributor.institutionFundação Oswaldo Cruz (FIOCRUZ)
dc.contributor.institutionHospital São Rafael
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHospital do Câncer A. C. Camargo
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionInstituto Nacional de Cardiologia (INC)
dc.contributor.institutionSociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE)
dc.date.accessioned2014-05-27T11:24:45Z
dc.date.available2014-05-27T11:24:45Z
dc.date.issued2010-08-01
dc.description.abstractChronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease. © 2010 by the Infectious Diseases Society of America.en
dc.description.affiliationCentro de Pesquisas Gonçalo Moniz Fundação Oswaldo Cruz
dc.description.affiliationHospital São Rafael, Salvador
dc.description.affiliationDepartamento de Urologia Faculdade de Medicina Universidade do Estado de São Paulo, Botucatu
dc.description.affiliationHospital do Câncer A. C. Camargo, São Paulo
dc.description.affiliationInstituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro
dc.description.affiliationInstituto Nacional de Cardiologia, Rio de Janeiro
dc.description.affiliationD. P. Purpura Department of Neuroscience Albert Einstein College of Medicine, Bronx, NY
dc.description.affiliationDepartment of Medicine Albert Einstein College of Medicine, Bronx, NY
dc.description.affiliationDepartment of Pathology Albert Einstein College of Medicine, Bronx, NY
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.format.extent416-426
dc.identifierhttp://dx.doi.org/10.1086/653481
dc.identifier.citationJournal of Infectious Diseases, v. 202, n. 3, p. 416-426, 2010.
dc.identifier.doi10.1086/653481
dc.identifier.issn0022-1899
dc.identifier.lattes2259986546265579
dc.identifier.scopus2-s2.0-77954738641
dc.identifier.urihttp://hdl.handle.net/11449/71798
dc.language.isoeng
dc.relation.ispartofJournal of Infectious Diseases
dc.relation.ispartofjcr5.186
dc.relation.ispartofsjr3,302
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectactin binding protein
dc.subjectbeta3 integrin
dc.subjectcathepsin
dc.subjectcathepsin H
dc.subjectcathepsin S
dc.subjectCD11b antigen
dc.subjectCD38 antigen
dc.subjectCD4 antigen
dc.subjectCD52 antigen
dc.subjectCD8 antigen
dc.subjectcell adhesion molecule
dc.subjectcell surface protein
dc.subjectchemokine
dc.subjectchemokine receptor
dc.subjectchlordane
dc.subjectcytokine receptor
dc.subjectgalectin 3
dc.subjectgamma interferon
dc.subjectintercellular adhesion molecule 1
dc.subjectinterleukin 10 receptor alpha
dc.subjectmatrix metalloproteinase 14
dc.subjectmetalloproteinase inhibitor
dc.subjectPADGEM protein
dc.subjectprotein lysine 6 oxidase
dc.subjecttumor necrosis factor alpha
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcell proliferation
dc.subjectChagas disease
dc.subjectchronic disease
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene expression
dc.subjectheart failure
dc.subjectheart muscle
dc.subjectheart muscle fibrosis
dc.subjecthistocompatibility complex
dc.subjectimmune response
dc.subjectimmune response gene
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectintracellular signaling
dc.subjectmale
dc.subjectmicroarray analysis
dc.subjectmouse
dc.subjectmyocarditis
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectpathogenesis
dc.subjectphosphate transport
dc.subjectpriority journal
dc.subjectTrypanosoma cruzi
dc.subjectupregulation
dc.titleGene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathyen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policya1.html
unesp.author.lattes2259986546265579
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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