Is urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants?

Página do item simplificado
dc.contributor.authorBentlin, Maria Regina [UNESP]
dc.contributor.authorRugolo, Ligia Maria Suppo de Souza [UNESP]
dc.contributor.authorRugolo, Antonio
dc.contributor.authorHashimoto, Miriam [UNESP]
dc.contributor.authorLyra, João César [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:52Z
dc.date.available2014-05-20T13:37:52Z
dc.date.issued2007-12-01
dc.description.abstractThe present study is aimed to determine serum and urine interleukin-8 (IL-8) levels in premature infants with late onset sepsis (LOS) and to evaluate if urine IL-8 is a useful test for LOS diagnosis. Fifty-six premature infants admitted to the NICU over 1 year had serum and urine IL-8 determined by ELISA. They were divided into three groups: I definite sepsis, II probable sepsis and III non-infected. Results were expressed as mean or median. Differences between groups were assessed by ANOVA, Kruskal-Wallis ANOVA and Dunns Method. Sensitivity, specificity and positive and negative predictive values were calculated and a receiver operator characteristic curve was constructed to determine serum and urine IL-8 accuracy. There were no differences between groups for birth weight, and gestational and post-natal age. Median serum and urine IL-8 levels were significantly higher in GI and GII: 929 x 906 x 625pg/ml; P=0.024, and 249 x 189 x 42pg/mgCr; P< 0.001. Optimal cut-off point was 625pg/ml for serum IL-8 with 69 sensitivity and 75pg/mgCr for urine IL-8 with 92 sensitivity. IL-8 can be determined in urine from premature infants with LOS and is an accurate and feasible diagnosis method.en
dc.description.affiliationUNESP, Fac Med Botucatu, Dept Pediat, Dist Rubiao Jr, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Med Botucatu, Dept Pediat, Dist Rubiao Jr, BR-18618000 Botucatu, SP, Brazil
dc.format.extent403-408
dc.identifierhttp://dx.doi.org/10.1093/tropej/fmm054
dc.identifier.citationJournal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 53, n. 6, p. 403-408, 2007.
dc.identifier.doi10.1093/tropej/fmm054
dc.identifier.issn0142-6338
dc.identifier.lattes2559637400719543
dc.identifier.lattes1197755531108177
dc.identifier.lattes1446883241749717
dc.identifier.urihttp://hdl.handle.net/11449/13122
dc.identifier.wosWOS:000251988800007
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofJournal of Tropical Pediatrics
dc.relation.ispartofjcr1.187
dc.relation.ispartofsjr0,673
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleIs urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants?en
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dcterms.rightsHolderOxford Univ Press
unesp.author.lattes2559637400719543
unesp.author.lattes1197755531108177
unesp.author.lattes5891976829231996[3]
unesp.author.lattes1446883241749717
unesp.author.orcid0000-0002-1715-3893[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Pediatria - FMB