Virulence profiles of ten Paracoccidioides brasiliensis isolates obtained from armadillos (Dasypus novemcinctus)

Página do item simplificado
dc.contributor.authorHebeler-Barbosa, F.
dc.contributor.authorMontenegro, M. R.
dc.contributor.authorBagagli, E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:36:56Z
dc.date.available2014-05-20T13:36:56Z
dc.date.issued2003-04-01
dc.description.abstractParacoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis ( PCM), the most important systemic mycosis in Latin America. The armadillo, Dasypus novemcinctus, has been confirmed as the primary natural reservoir of this fungus. Its geographic distribution is similar to that of human PCM. In this study, virulence profiles of 10 P. brasiliensis isolates from different armadillos and of two clinical isolates were tested in an experimental hamster model. Pathogenicity was evaluated by counting cfu and performing histopathological analysis in the testis, liver, spleen and lung. Circulating specific antibodies were measured using enzyme- linked immunosorbent assay ( ELISA). All isolates from armadillos were virulent in the model, with dissemination to many organs. The clinical isolates, which had long been stored in cultured collections, were less virulent. The isolates were classified into four virulence categories according to number of cfu per gram of tissue: very high, high, intermediate and low. This study confirms that armadillos harbor pathogenic genotypes of P. brasiliensis, probably the same ones that infect humans.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18600000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med, Dept Patol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18600000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Dept Patol, Botucatu, SP, Brazil
dc.format.extent89-96
dc.identifierhttp://dx.doi.org/10.1080/714043903
dc.identifier.citationMedical Mycology. Abingdon: Taylor & Francis Ltd, v. 41, n. 2, p. 89-96, 2003.
dc.identifier.doi10.1080/714043903
dc.identifier.issn1369-3786
dc.identifier.lattes3320327570429539
dc.identifier.urihttp://hdl.handle.net/11449/12724
dc.identifier.wosWOS:000226559700002
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofMedical Mycology
dc.relation.ispartofjcr2.799
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectarmadillospt
dc.subjectDasypus novemcinctuspt
dc.subjecthamsterpt
dc.subjectP. brasiliensispt
dc.subjectvirulencept
dc.titleVirulence profiles of ten Paracoccidioides brasiliensis isolates obtained from armadillos (Dasypus novemcinctus)en
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.lattes3320327570429539
unesp.author.orcid0000-0002-8003-4109[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Microbiologia e Imunologia - IBB
Artigos - Patologia - FMB