Expression of the classical and nonclassical HLA molecules in breast cancer

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dc.contributor.authorSilva, Gisela Bevilacqua Rolfsen Ferreira da [UNESP]
dc.contributor.authorSilva, Tarsia Giabardo Alves [UNESP]
dc.contributor.authorDuarte, Roberta Aparecida [UNESP]
dc.contributor.authorNeto, Nicolino Lia
dc.contributor.authorCarrara, Hélio Humberto Angotti
dc.contributor.authorDonadi, Eduardo Antônio
dc.contributor.authorGonçalves, Maria Alice Guimarães
dc.contributor.authorSoares, Edson Garcia
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstitute of Surgical Pathology and Cytopathology
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:30:24Z
dc.date.available2015-12-07T15:30:24Z
dc.date.issued2013
dc.description.abstractConsidering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly differentiated) and to the presence of metastases in axillary lymph nodes. The expression of HLA molecules was assessed by immunohistochemistry, using a computer-assisted system. Overall, 31 (59.6%) out of the 52 IDC breast biopsies exhibited high expression of HLA-G, but only 14 (26.9%) showed high expression of HLA-E. A large number (41, 78.8%) of the biopsies showed low expression of HLA-Ia, while 45 (86.5%) showed high expression of HLA-DQ and 36 (69.2%) underexpressed HLA-DR. Moreover, 24 (41.2%) of 52 biopsies had both low HLA-Ia expression and high HLA-G expression, while 11 (21.2%) had low HLA-Ia expression and high HLA-E expression. These results suggest that, by different mechanisms, the downregulation of HLA-Ia, HLA-E, and HLA-DR and the upregulation of HLA-G and HLA-DQ are associated with immune response evasion and breast cancer aggressiveness.en
dc.description.affiliationDepartment of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, SP, Brazil ; Department of Clinical Analysis, Laboratory of Cytology and Cell Biology, Faculty of Pharmaceutical Sciences, UNESP, Rua Expedicionários do Brasil 1621, 14801-902 Araraquara, SP, Brazil.
dc.description.affiliationDepartment of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, SP, Brazil.
dc.description.affiliationInstitute of Surgical Pathology and Cytopathology, Araraquara, SP, Brazil.
dc.description.affiliationDivision of Clinical Immunology, Department of Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.
dc.description.affiliationDepartment of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), SP, Brazil.
dc.description.affiliationUnespDepartment of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, SP, Brazil ; Department of Clinical Analysis, Laboratory of Cytology and Cell Biology, Faculty of Pharmaceutical Sciences, UNESP, Rua Expedicionários do Brasil 1621, 14801-902 Araraquara, SP, Brazil.
dc.description.affiliationUnespDepartment of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, SP, Brazil.
dc.identifierhttp://dx.doi.org/10.1155/2013/250435
dc.identifier.citationInternational Journal Of Breast Cancer, v. 2013, 2013.
dc.identifier.doi10.1155/2013/250435
dc.identifier.issn2090-3170
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.pmcPMC3864140
dc.identifier.pubmed24363939
dc.identifier.urihttp://hdl.handle.net/11449/130954
dc.language.isoeng
dc.publisherInternational Journal Of Breast Cancer
dc.relation.ispartofInternational Journal Of Breast Cancer
dc.relation.ispartofsjr1,025
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.titleExpression of the classical and nonclassical HLA molecules in breast canceren
dc.typeArtigo
unesp.author.lattes1768025290373669[9]
unesp.author.orcid0000-0003-1740-7360[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR