PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY

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dc.contributor.authorFernandes Guerreiro, Joao Paulo [UNESP]
dc.contributor.authorLima, Diogenes Rodrigues
dc.contributor.authorBordignon, Glaucia
dc.contributor.authorDanieli, Marcus Vinicius [UNESP]
dc.contributor.authorQueiroz, Alexandre Oliveira
dc.contributor.authorCataneo, Daniele Cristina [UNESP]
dc.contributor.institutionHosp Ortoped Uniorte
dc.contributor.institutionHosp Evangel Londrina
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T16:57:38Z
dc.date.available2020-12-10T16:57:38Z
dc.date.issued2019-09-01
dc.description.abstractObjective: To evaluate the efficacy of platelet-rich plasma (PRP) and tranexamic acid (TXA) applied in total knee arthroplasty. Methods: We selected and randomized 84 patients. TXA was applied in 23 patients, PRP in 20, and PRP in combination with TXA in 20. Hemoglobin was measured preoperatively and 24 and 48 hours postoperatively. The function questionnaire, pain scale and gain of knee flexion were monitored until the second postoperative year. Results: There was a difference (p <0.01) in the decrease in hemoglobin 48 hours after surgery between the TXA group and the control and PRP groups. In terms of pain, the TXA group at 24 and 48 hours after surgery and the PRP group at 48 hours after surgery showed advantages (p <0.01). Knee flexion gain in the first 24 hours postoperatively was better in the TXA group (p <0.05). Conclusion: TXA was effective in lowering the drop in hemoglobin level, reducing pain and improving movement gain 48 hours after the procedure. PRP was not effective in reducing bleeding or improving knee function after arthroplasty, but provided better control of postoperative pain.en
dc.description.affiliationHosp Ortoped Uniorte, Londrina, PR, Brazil
dc.description.affiliationHosp Evangel Londrina, Londrina, PR, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquite Filho, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquite Filho, Botucatu, SP, Brazil
dc.format.extent248-251
dc.identifierhttp://dx.doi.org/10.1590/1413-785220192705214417
dc.identifier.citationActa Ortopedica Brasileira. Sao Paulo Sp: Atha Comunicacao & Editora, v. 27, n. 5, p. 248-251, 2019.
dc.identifier.doi10.1590/1413-785220192705214417
dc.identifier.fileS1413-78522019000500248.pdf
dc.identifier.issn1413-7852
dc.identifier.scieloS1413-78522019000500248
dc.identifier.urihttp://hdl.handle.net/11449/194886
dc.identifier.wosWOS:000489135700002
dc.language.isoeng
dc.publisherAtha Comunicacao & Editora
dc.relation.ispartofActa Ortopedica Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectArthroplasty, Replacement, Knee
dc.subjectTranexamic Acid
dc.subjectPlatelet-Rich Plasma
dc.subjectHemorrhage
dc.subjectPain
dc.titlePLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTYen
dc.typeArtigo
dcterms.rightsHolderAtha Comunicacao & Editora
unesp.author.orcid0000-0001-5273-4303[3]

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