Biofilm formation by Candida albicans and Streptococcus mutans in the presence of farnesol: a quantitative evaluation

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dc.contributor.authorFernandes, Renan Aparecido [UNESP]
dc.contributor.authorMonteiro, Douglas Roberto [UNESP]
dc.contributor.authorArias, Laís Salomão [UNESP]
dc.contributor.authorFernandes, Gabriela Lopes [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorBarbosa, Debora Barros [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:24Z
dc.date.available2018-12-11T17:01:24Z
dc.date.issued2016-03-15
dc.description.abstractThe aim of this study was to evaluate the effect of the QS molecule farnesol on single and mixed species biofilms formed by Candida albicans and Streptococcus mutans. The anti-biofilm effect of farnesol was assessed through total biomass quantification, counting of colony forming units (CFUs) and evaluation of metabolic activity. Biofilms were also analyzed by scanning electron microscopy (SEM). It was observed that farnesol reduced the formation of single and mixed biofilms, with significant reductions of 37% to 90% and 64% to 96%, respectively, for total biomass and metabolic activity. Regarding cell viability, farnesol treatment promoted significant log reductions in the number of CFUs, ie 1.3–4.2 log10 and 0.67–5.32 log10, respectively, for single and mixed species biofilms. SEM images confirmed these results, showing decreases in the number of cells in all biofilms. In conclusion, these findings highlight the role of farnesol as an alternative agent with the potential to reduce the formation of pathogenic biofilms.en
dc.description.affiliationDepartment of Pediatric Dentistry and Public Health Aracatuba Dental School UNESP
dc.description.affiliationDepartment of Dental Materials and Prosthodontics Aracatuba Dental School UNESP
dc.description.affiliationUnespDepartment of Pediatric Dentistry and Public Health Aracatuba Dental School UNESP
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics Aracatuba Dental School UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/23592-0
dc.format.extent329-338
dc.identifierhttp://dx.doi.org/10.1080/08927014.2016.1144053
dc.identifier.citationBiofouling, v. 32, n. 3, p. 329-338, 2016.
dc.identifier.doi10.1080/08927014.2016.1144053
dc.identifier.file2-s2.0-84959360995.pdf
dc.identifier.issn1029-2454
dc.identifier.issn0892-7014
dc.identifier.scopus2-s2.0-84959360995
dc.identifier.urihttp://hdl.handle.net/11449/172605
dc.language.isoeng
dc.relation.ispartofBiofouling
dc.relation.ispartofsjr0,835
dc.relation.ispartofsjr0,835
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiofilms
dc.subjectCandida albicans
dc.subjectquorum sensing
dc.subjectStreptococcus mutans
dc.titleBiofilm formation by Candida albicans and Streptococcus mutans in the presence of farnesol: a quantitative evaluationen
dc.typeArtigo
unesp.author.lattes0421571920582994[5]
unesp.author.orcid0000-0002-8159-4853[5]

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Artigos - Odontologia Infantil e Social - FOA
Artigos - Materiais Odontológicos e Prótese - FOA