Magnetically drivable nano-bio-conjugate mimicking free curcumin redox behavior

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dc.contributor.authorMagro, Massimiliano
dc.contributor.authorCampos, Rene [UNESP]
dc.contributor.authorBaratella, Davide
dc.contributor.authorLima, Giuseppina Pace Pereira [UNESP]
dc.contributor.authorZboril, Radek
dc.contributor.authorVianello, Fabio
dc.contributor.institutionUniversity of Padova
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPalacky University
dc.date.accessioned2015-11-03T15:30:47Z
dc.date.available2015-11-03T15:30:47Z
dc.date.issued2014-01-01
dc.description.abstractCurcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be correlated to its potent antioxidant capacity. Novel maghemite (gamma-Fe3O4) nanoparticles, characterized by a diameter of about 10 nm and possessing peculiar colloidal properties and surface interactions, called Surface Active Maghemite Nanoparticles (SAMN), were superficially modified with curcumin by simple incubation, due to the presence of under-coordinated Fe(III) atoms on nanoparticle surface. The resulting curcumin-modified SAMNs (SAMN@curcumin) were characterized by transmission electron microscopy (TEM), FTIR, Mossbauer, EPR and UV-Vis spectroscopy. The redox properties of bound curcumin were tested by electrochemistry. Finally, SAMN@curcumin was studied in the presence of different electroactive substances, namely hydroquinone, NADH and ferrocyanide, in order to assess its electrochemical behavior. Moreover, SAMN@curcumin was electrochemically tested in the presence of one of the most diffuse reactive oxygen specie, such as hydrogen peroxide, demonstrating its stability. SAMN@curcumin in which curcumin is firmly bound, but still retaining its redox features represents a feasible adduct: a magnetically drivable nano-bio-conjugate mimicking free Curcumin redox behavior. The proposed nanostructured material could be exploited as magnetic drivable curcumin vehicle for biomedical applications.en
dc.description.affiliationPalacky University in Olomouc, Olomouc, Czech Republic, EU.
dc.description.affiliationUniversity of Padova, Padova, Italy, EU.
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil
dc.format.extent654-658
dc.identifierhttp://konsys-t.tanger.cz/files/proceedings/14/reports/2319.pdf
dc.identifier.citationNanocon 2013, 5th International Conference. Slezska: Tanger Ltd, p. 654-658, 2014.
dc.identifier.lattes8104143593771412
dc.identifier.urihttp://hdl.handle.net/11449/130261
dc.identifier.wosWOS:000352070900116
dc.language.isoeng
dc.publisherTanger Ltd
dc.relation.ispartofNanocon 2013, 5th International Conference
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCurcuminen
dc.subjectMaghemite nanoparticlesen
dc.subjectNanomaterial electrocatalysisen
dc.subjectHydrogen peroxideen
dc.subjectNADH oxidationen
dc.titleMagnetically drivable nano-bio-conjugate mimicking free curcumin redox behavioren
dc.typeTrabalho apresentado em evento
dcterms.rightsHolderTanger Ltd
unesp.author.lattes8104143593771412
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Química e Bioquímica - IBB