Is the BCG Vaccine Safe for Undernourished Individuals?

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dc.contributor.authorWatanabe Ishikawa, Larissa Lumi [UNESP]
dc.contributor.authorda Rosa, Larissa Camargo [UNESP]
dc.contributor.authorDonega Franca, Thais Graziela [UNESP]
dc.contributor.authorPeres, Raphael Sanches [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorGoncalves Zorzella-Pezavento, Sofia Fernanda [UNESP]
dc.contributor.authorSartori, Alexandrina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:11Z
dc.date.available2014-05-20T13:51:11Z
dc.date.issued2012-01-01
dc.description.abstractCellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition. The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals. An experimental model of undernutrition was established by subjecting BALB/c mice to dietary restriction. These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined. A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver. In addition, only undernourished animals had bacteria in the lungs and thymus. Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-alpha, IFN-gamma, and IL-10 was also diminished in these mice. Taken together, these results indicate that BCG infection is more severe in undernourished mice. Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.en
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1155/2012/673186
dc.identifier.citationClinical & Developmental Immunology. New York: Hindawi Publishing Corporation, p. 6, 2012.
dc.identifier.doi10.1155/2012/673186
dc.identifier.fileWOS000303751300001.pdf
dc.identifier.issn1740-2522
dc.identifier.lattes4977572416129527
dc.identifier.urihttp://hdl.handle.net/11449/18275
dc.identifier.wosWOS:000303751300001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofClinical & Developmental Immunology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleIs the BCG Vaccine Safe for Undernourished Individuals?en
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes4977572416129527[7]
unesp.author.orcid0000-0001-9030-0768[6]
unesp.author.orcid0000-0003-4557-3331[7]
unesp.author.orcid0000-0003-3481-2181[1]
unesp.author.orcid0000-0002-0417-779X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB