Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection

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dc.contributor.authorGrotto, Rejane Maria Tommasini [UNESP]
dc.contributor.authorPicelli, Natália [UNESP]
dc.contributor.authorSouza, Lenice do Rosário de[UNESP]
dc.contributor.authorSilva, Giovanni Faria [UNESP]
dc.contributor.authorFerrasi, Adriana Camargo [UNESP]
dc.contributor.authorSilveira, Liciana Vaz de Arruda [UNESP]
dc.contributor.authorPardini, Maria Inês de Moura Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:31:34Z
dc.date.available2015-12-07T15:31:34Z
dc.date.issued2015
dc.description.abstractTo evaluate the associations of HPA polymorphisms -1, -3, and -5 with HIV/HCV coinfection were included in this study 60 HIV/HCV-coinfected patients from the Sao Paulo State health service centers. Data reported by Verdichio-Moraes et al. (2009: J. Med Virol 81:757-759) were used as the non-infected and HCV monoinfected groups. Human Platelet Polymorphism genotyping was performed in 60 Patients co-infected with HIV/HCV by PCR-SSP or PCR-RFLP. HIV subtyping and HCV genotyping was performed by RT-PCR followed sequencing. The data analyses were performed using the χ2 test or Fisher's Exact Test and the logistic regression model. Patients coinfected with HIV/HCV presented HCV either genotype 1 (78.3%) or non-1 (21.7%) and HIV either subtype B (85.0%) or non-B (15%). The Human Platelet Polymorphism-1a/1b genotype was more frequent (P < 0.05) in HIV/HCV coinfection than in HCV monoinfection and the allelic frequency of Human Platelet Polymorphism-5b in the Patients coinfected with HIV/HCV was higher (P < 0.05) than in HCV monoinfected cases and non-infected individuals. These data suggest that the presence of specific HPA allele on platelets could favor the existence of coinfection. On the other hand, Human Platelet Polymorphism-5a/5b was more frequent (P < 0.05) in HIV/HCV coinfected and HCV monoinfected groups than in the non-infected individuals, suggesting that this platelet genotype is related to HCV infection, regardless of HIV presence. Results suggest that the Human Platelet Polymorphism profile in HIV/HCV coinfected individuals differs from the one of both HCV monoinfected and non-infected population. So, the Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection.en
dc.description.affiliationMolecular Biology Laboratory, Blood Transfusion Center, Botucatu Medical School, Sao Paulo State University, UNESP, São Paulo, Brazil.
dc.description.affiliationDepartment of Bioprocess and Biotechnology, School of Agricultural Sciences, Lageado Experiment Station. Sao Paulo State University, UNESP, Botucatu-SP, Brazil.
dc.description.affiliationTropical Diseases Department, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
dc.description.affiliationDepartment of Internal Medicine, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
dc.description.affiliationDepartment of Biostatistics, Institute of Bioscience, UNESP, São Paulo, Brazil.
dc.description.affiliationUnespMolecular Biology Laboratory, Blood Transfusion Center, Botucatu Medical School, Sao Paulo State University, UNESP, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Bioprocess and Biotechnology, School of Agricultural Sciences, Lageado Experiment Station. Sao Paulo State University, UNESP, Botucatu-SP, Brazil.
dc.description.affiliationUnespTropical Diseases Department, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Internal Medicine, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Biostatistics, Institute of Bioscience, UNESP, São Paulo, Brazil.
dc.format.extent1677-1681
dc.identifierhttp://dx.doi.org/10.1002/jmv.24233
dc.identifier.citationJournal Of Medical Virology, v. 87, n. 10, p. 1677-1681, 2015.
dc.identifier.doi10.1002/jmv.24233
dc.identifier.issn1096-9071
dc.identifier.lattes6322604200510676
dc.identifier.lattes3587895085226224
dc.identifier.lattes7805298466001457
dc.identifier.lattes4619588334582084
dc.identifier.lattes7788448564326585
dc.identifier.orcid0000-0001-9200-5391
dc.identifier.orcid0000-0002-4035-9486
dc.identifier.pubmed25976501
dc.identifier.urihttp://hdl.handle.net/11449/131097
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Medical Virology
dc.relation.ispartofsjr0,978
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectHIV/HVC coinfectionen
dc.subjectHuman platelet polymorphism -1en
dc.subjectHuman platelet polymorphism -3en
dc.subjectHuman platelet polymorphism -5en
dc.subjectPolymorphismen
dc.titleHuman Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfectionen
dc.typeArtigo
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes3587895085226224[4]
unesp.author.lattes6322604200510676
unesp.author.lattes7805298466001457[6]
unesp.author.lattes4619588334582084
unesp.author.lattes7788448564326585[1]
unesp.author.orcid0000-0001-9200-5391[4]
unesp.author.orcid0000-0001-8931-5495[6]
unesp.author.orcid0000-0002-4035-9486[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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