Oral leukoplakia—epidemiological survey and histochemical analysis of 107 cases in Brazil

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dc.contributor.authorDogenski, Letícia Copatti
dc.contributor.authorde Figueiredo Ribeiro, Sara
dc.contributor.authorGambin, Diego José
dc.contributor.authorMaso, Patrícia Canova
dc.contributor.authorLinden, Maria Salete Sandini
dc.contributor.authorTrentin, Micheline Sandini
dc.contributor.authorZoehler, Bernardo
dc.contributor.authorCrivelini, Marcelo Macedo [UNESP]
dc.contributor.authorDe Carli, João Paulo
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversity of Passo Fundo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:47:09Z
dc.date.available2020-12-12T02:47:09Z
dc.date.issued2020-01-01
dc.description.abstractObjective: To perform an epidemiological survey comparing the cell proliferative activity of 107 cases of oral leukoplakia with their clinical and histopathological characteristics. Materials and methods: A cross-sectional, observational, and histological-histochemical study. The cases came from the Histopathological Diagnostic Service of UPF/RS and the School of Dentistry of Araçatuba FOA/UNESP/SP (1986–2016). The histopathological sections were stained using the silver staining (AgNOR) technique and the nuclei of 100 epithelial cells selected randomly were recorded to count the number of nucleolar organizer regions (NORs). The mean NORs per lesion were correlated to clinical and histological characteristics using ANOVA, at 5% significance. Results: Most of the cases included men (62.62%), white (64.49%), and with an average age of 53.94 years. The most probable etiological factors were smoking (44.7%) and alcohol consumption (9.85%). The evolution time of most lesions was fast (33.65%), manifesting mainly in the form of plaques (70.37%) and without symptoms (58.88%). They were located mainly in the cheek mucosa (26.62%) and presented white color (66.35%), well-defined edges (59.81%), firm consistency (47.5%), and keratinized surface (49.53%). Etiological factor (p = 0.003), evolution time (p = 0.006), symptoms (p = 0.029), location (p = 0.020), consistency (p = 0.047), histopathological characteristics (p = 0.004), and superficial keratinization (p = 0.001) were statistically significant regarding the mean NORs of the leukoplakias studied. Clinical relevance: Oral leukoplakias caused by alcohol consumption and/or tobacco use, considering an evolution time of fewer than 12 months, asymptomatic, located in the lower lip or tongue, and with a firm consistency and increased superficial keratinization should be treated more aggressively by the clinician to avoid cancerization.en
dc.description.affiliationPost-Graduate Program in Oral Diagnosis Faculty of Dentistry Federal University of Santa Catarina
dc.description.affiliationFaculty of Dentistry University of Passo Fundo
dc.description.affiliationPost-Graduate Program in Dentistry Faculty of Dentistry University of Passo Fundo
dc.description.affiliationDepartment of Implantology Faculty of Dentistry University of Passo Fundo
dc.description.affiliationDepartment of Periodontics Faculty of Dentistry University of Passo Fundo
dc.description.affiliationInstitude of Biological Sciences University of Passo Fundo
dc.description.affiliationDepartment of Oral Pathology Faculty of Dentistry Júlio de Mesquita Filho São Paulo State University (UNESP)
dc.description.affiliationDepartments of Oral Medicine and Prosthodontics Faculty of Dentistry University of Passo Fundo
dc.description.affiliationUnespDepartment of Oral Pathology Faculty of Dentistry Júlio de Mesquita Filho São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03488-x
dc.identifier.citationClinical Oral Investigations.
dc.identifier.doi10.1007/s00784-020-03488-x
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.scopus2-s2.0-85089082571
dc.identifier.urihttp://hdl.handle.net/11449/201995
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.sourceScopus
dc.subjectAgNOR
dc.subjectHistological classification
dc.subjectLeukoplakia
dc.subjectPrognosis
dc.titleOral leukoplakia—epidemiological survey and histochemical analysis of 107 cases in Brazilen
dc.typeArtigo
unesp.author.orcid0000-0001-6174-5485[1]
unesp.author.orcid0000-0003-3975-7839[2]
unesp.author.orcid0000-0002-7720-7646[3]
unesp.author.orcid0000-0003-0074-896X[4]
unesp.author.orcid0000-0003-2873-1318[5]
unesp.author.orcid0000-0001-5040-3578[6]
unesp.author.orcid0000-0002-1208-4411[7]
unesp.author.orcid0000-0002-0174-439X[8]
unesp.author.orcid0000-0002-4705-6226[9]

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