Genetic Responses to Nanostructured Calcium-phosphate-coated Implants

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dc.contributor.authorJimbo, R.
dc.contributor.authorXue, Y.
dc.contributor.authorHayashi, M.
dc.contributor.authorSchwartz-Filho, H. O. [UNESP]
dc.contributor.authorAndersson, M.
dc.contributor.authorMustafa, K.
dc.contributor.authorWennerberg, A.
dc.contributor.institutionMalmo Univ
dc.contributor.institutionUniv Bergen
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionChalmers
dc.date.accessioned2013-09-30T18:31:48Z
dc.date.accessioned2014-05-20T13:45:23Z
dc.date.available2013-09-30T18:31:48Z
dc.date.available2014-05-20T13:45:23Z
dc.date.issued2011-12-01
dc.description.abstractNanostructured calcium phosphate (CaP) has been histologically and biomechanically proven to enhance osseointegration of implants; however, conventional techniques were not sufficiently sensitive to capture its biological effects fully. Here, we compared the conventional removal torque (RTQ) evaluation and gene expression in tissues around nanostructured CaP-coated implants, using real-time RT-PCR, with those of uncoated implants, in a rabbit model. At 2 wks, RTQ values were significantly higher, alkaline phosphatase (ALP) expression was significantly higher, and runt-related transcription factor 2 and tumor necrosis factor-alpha expressions were significantly lower in the coated than in the uncoated implants. This indicates that inflammatory responses were suppressed and osteoprogenitor activity increased around the CaP-coated surface. At 4 wks, although RTQ values did not significantly differ between the 2 groups, ALP and osteocalcin (OCN) were significantly up-regulated in the coated group, indicating progressive mineralization of the bone around the implant. Moreover, an osteoclast marker, adenosine triphosphatase, which indicates acidification of the resorption lacunae, was significantly higher for the coated implants, suggesting gradual resorption of the CaP coating. This study reveals detailed genetic responses to nanostructured CaP-coated implants and provides evidence that the effect of nanotopography is significant during the osseointegration cascade.en
dc.description.affiliationMalmo Univ, Surface Biol Grp, Dept Prosthodont, Fac Odontol, S-20506 Malmo, Sweden
dc.description.affiliationUniv Bergen, Ctr Clin Dent Res, Dept Clin Dent, N-5020 Bergen, Norway
dc.description.affiliationSão Paulo State Univ, UNESP, Div Periodontol, Dept Oral Diag & Surg,Sch Dent, Araraquara, SP, Brazil
dc.description.affiliationChalmers, Dept Chem & Biol Engn, S-41296 Gothenburg, Sweden
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Div Periodontol, Dept Oral Diag & Surg,Sch Dent, Araraquara, SP, Brazil
dc.description.sponsorshipSwedish Knowledge Foundation
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipHjalmar Svensson Research Foundation
dc.format.extent1422-1427
dc.identifierhttp://dx.doi.org/10.1177/0022034511422911
dc.identifier.citationJournal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 90, n. 12, p. 1422-1427, 2011.
dc.identifier.doi10.1177/0022034511422911
dc.identifier.issn0022-0345
dc.identifier.urihttp://hdl.handle.net/11449/15963
dc.identifier.wosWOS:000296982800009
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Dental Research
dc.relation.ispartofjcr5.380
dc.relation.ispartofsjr2,302
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgene expressionen
dc.subjectbiomaterialsen
dc.subjectnanotopographyen
dc.subjectbone implant interactionsen
dc.subjectosseointegrationen
dc.subjectcalcium phosphate coatingen
dc.titleGenetic Responses to Nanostructured Calcium-phosphate-coated Implantsen
dc.typeArtigo
dcterms.licensehttps://mc.manuscriptcentral.com/societyimages/wes/WES_ExclusiveLicense.pdf
dcterms.rightsHolderSage Publications Inc
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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