High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report

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dc.contributor.authorSantiago, Aline Evangelista [UNESP]
dc.contributor.authorTeunissen, Nicky
dc.contributor.authorRicardo, Bernardo Ferreira De Paula
dc.contributor.authorCândido, Eduardo Batista
dc.contributor.authorFurtado, Rafaela De Souza
dc.contributor.authorSilva Filho, Agnaldo Lopes Da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniveridade Federal de Minas Gerais
dc.contributor.institutionHospital MaterDei
dc.date.accessioned2022-04-28T19:48:53Z
dc.date.available2022-04-28T19:48:53Z
dc.date.issued2021-12-01
dc.description.abstractIntroduction In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors. Case Report A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V-Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy. Conclusion As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.en
dc.description.affiliationGynecology Department Universidade Estadual Paulista Júlio de Mesquita Filho, SP
dc.description.affiliationGynecology Department Univeridade Federal de Minas Gerais, MG
dc.description.affiliationPathology Department Hospital MaterDei, MG
dc.description.affiliationGynecology Department Hospital MaterDei, MG
dc.description.affiliationUnespGynecology Department Universidade Estadual Paulista Júlio de Mesquita Filho, SP
dc.format.extent980-984
dc.identifierhttp://dx.doi.org/10.1055/s-0041-1736301
dc.identifier.citationRevista Brasileira de Ginecologia e Obstetricia, v. 43, n. 12, p. 980-984, 2021.
dc.identifier.doi10.1055/s-0041-1736301
dc.identifier.issn0100-7203
dc.identifier.scopus2-s2.0-85122146079
dc.identifier.urihttp://hdl.handle.net/11449/223143
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Ginecologia e Obstetricia
dc.sourceScopus
dc.subjectadenoid cystic carcinoma
dc.subjectBartholin gland
dc.subjectgynecology
dc.subjectoncology
dc.subjectvulvar neoplasms
dc.titleHigh-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Reporten
dc.typeArtigo

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